[Enhancement of the effect of radiotherapy of Guerin's carcinoma by tinidazole]. / Usilenie luchevogo vozdeistviia na kartsinomu Gerena s pomoshch'iu tinidazola.

Tinidazol, an electron-acceptor compound, was studied for its influence on the effectiveness of radiation treatment of Guerin's carcinoma. It was shown in terms of tumour regression, percentage of inhibition, time of tumour volume doubling, rate of the tumour growth renewal and average survival that in the presence of tinidazol, the antitumour effectiveness of radiation treatment is 1.6-2.0 times as high as radiation alone. Morphologic studies confirm the ability of tinidazol to enhance the radiation damage.

[Acid-base equilibrium in rectal cancer under combined therapy]. / Kislotno-shchelochnoe ravnovesie u bol'nykh rakom priamoi kishki pri kombinirovannom lechenii.

Under study were the indices of the acid-base condition of blood in 49 patients with rectal cancer at different stages of the combined therapy (intensive telegamma therapy and surgery). The control group comprised 47 analogous patients subjected to surgical therapy solely. A mixed respiratory-metablic acidosis with signs of tissue hypoxia was noted prior to the treatment. Following irradiation and during the operative procedure these changes would aggravate. In irradiated patients these disorders are manifest to a greater extent and age dependent on the duration of the operative procedure, blood losses and the amount of transfused donor blood. If there are no complications, then such disorders resume their initial level or are normalized to the 1st-3d day postoperatively. To correct metabolic acidosis in the irradiated patients more intesive medication measures would be required.