Subject(s)
Fibrinogens, Abnormal , Fibronectins/isolation & purification , Leukapheresis/methods , Lymph/cytology , Scleroderma, Systemic/therapy , Adult , Cryoglobulins/analysis , Evaluation Studies as Topic , Female , Fibrinogen/analysis , Fibronectins/blood , Humans , Immunoglobulins/analysis , Lymph/chemistry , Male , Middle Aged , Scleroderma, Systemic/metabolismSubject(s)
Arthritis, Rheumatoid/blood , Autoimmune Diseases/blood , Cryoglobulinemia/etiology , Cryoglobulins/analysis , Immunoglobulins/analysis , Lupus Erythematosus, Systemic/blood , Rheumatoid Factor/analysis , Sjogren's Syndrome/blood , Adult , Animals , Arthritis, Rheumatoid/complications , Arthritis, Rheumatoid/immunology , Autoimmune Diseases/complications , Autoimmune Diseases/immunology , Cryoglobulinemia/classification , Cryoglobulinemia/immunology , Cryoglobulins/classification , Cryoglobulins/immunology , Humans , Immunoglobulins/classification , Immunoglobulins/immunology , Lupus Erythematosus, Systemic/complications , Lupus Erythematosus, Systemic/immunology , Mice , Middle Aged , Rheumatoid Factor/immunology , Sjogren's Syndrome/complications , Sjogren's Syndrome/immunologySubject(s)
Antigen-Antibody Complex/analysis , Arthritis, Rheumatoid/diagnosis , Immune Complex Diseases/diagnosis , Lupus Erythematosus, Systemic/diagnosis , Polyethylene Glycols , Arthritis, Rheumatoid/immunology , Blood Sedimentation/drug effects , Humans , Immune Complex Diseases/immunology , Immunoenzyme Techniques , Lupus Erythematosus, Systemic/immunology , Polyethylene Glycols/pharmacologyABSTRACT
Sixty patients with systemic lupus erythematosus (SLE) were examined: 40 patients with cryoglobulinemia and 20 patients without it. Cryoglobulinemia was observed in patients with SLE, as a rule, in the acute course of the disease ending in renal affection. Cryoglobulinemia in SLE was accompanied by the phenomenon of generalized vasculitis in the form of skin and mucosa lesions with ulcero-necrotic changes and affections of the central and peripheral nervous system and the kidneys. The clinical picture of SLE accompanied by cryoglobulinemia was characterized by a polysyndrome phenomenon and infrequent presence of the ARA criteria. Cryoglobulinemia was accompanied by high titres of anti-DNA. Thus, cryoglobulinemia can be regarded as one of the important factors of immunocomplex damage in SLE.
Subject(s)
Antibodies, Antinuclear/analysis , Antigen-Antibody Complex/analysis , Autoimmune Diseases/diagnosis , Cryoglobulins/analysis , Immune Complex Diseases/diagnosis , Lupus Erythematosus, Systemic/diagnosis , Adolescent , Adult , Autoimmune Diseases/immunology , DNA/immunology , Female , Humans , Immune Complex Diseases/immunology , Lupus Erythematosus, Systemic/genetics , Lupus Erythematosus, Systemic/immunology , Male , Middle AgedABSTRACT
EIA was used to measure the concentration of fibronectin in plasma and cryoprecipitates of 37 patients suffering from systemic lupus erythematosus coupled with cryoglobulinemia. A definite relationship was discovered between the level of cryoglobulins and the activity of SLE, the concentration of fibronectin in plasma and liver damage. A tendency was revealed towards increase of the fibronectin content in plasma of patients with a high level of antibodies to native DNA and CIC as was a significant correlation between the concentration of cryoglobulin protein and the concentration of fibronectin in cryoprecipitates.
