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J Pharm Biomed Anal ; 40(1): 51-5, 2006 Jan 23.
Article in English | MEDLINE | ID: mdl-16102931

ABSTRACT

A multivariate method of analysis of nystatin and metronidazole in a semi-solid matrix, based on diffuse reflectance NIR measurements and partial least squares regression, is reported. The product, a vaginal cream used in the antifungal and antibacterial treatment, is usually, quantitatively analyzed through microbiological tests (nystatin) and HPLC technique (metronidazole), according to pharmacopeial procedures. However, near infrared spectroscopy has demonstrated to be a valuable tool for content determination, given the rapidity and scope of the method. In the present study, it was successfully applied in the prediction of nystatin (even in low concentrations, ca. 0.3-0.4%, w/w, which is around 100,000 IU/5g) and metronidazole contents, as demonstrated by some figures of merit, namely linearity, precision (mean and repeatability) and accuracy.


Subject(s)
Metronidazole/chemistry , Nystatin/chemistry , Spectroscopy, Near-Infrared/methods , Anti-Bacterial Agents/analysis , Antifungal Agents/analysis , Calibration , Least-Squares Analysis , Metronidazole/isolation & purification , Multivariate Analysis , Nystatin/isolation & purification , Regression Analysis , Reproducibility of Results
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