[An unusual case of a basophilic variant of chronic myelogenous leukemia]. / Ein ungewöhnlicher Fall der basophilen Variante einer chronischen Myelose.

The described basophilic variant of CML in blastic crisis was characterized by a distinct hyperhistaminemia, a moderate hypocoagulation and an insufficiently effective cytostatic therapy. Cell kinetic was characterized by a marked diminution of the whole marketing index (with H3-thymidine) of blasts and immature basophils with simultaneous prolongation of the generation time in comparison to myeloblasts at the chronic stage of the CML. Aneuploid cell clones prevailed in the bone-marrow.

[Characteristics of clonal evolution in patients with myelocytic leukemia]. / Osobennosti klonal'noi evoliutsii u bol'nykh khronicheskim mieloleikozom.

The authors report the results of the clinical, cytochemical, cytogenetic and kinetic studies (3H-thymidine autoradiography and scanning integrating cytospectrophotometry of DNA) in a male patient with chronic myeloleukemia with blast infiltration of the lymph nodes. Analysis of the karyotype and kinetic aspects of leukemic cells obtained from the blood, bone marrow, spleen and hyperplastic lymph nodes was performed over time at different disease periods. Based on the data obtained the authors suggest that aneuploid blasts may maturate before segmented granulocytes. The probability of the medullary origin of aneuploid clones is discussed.

[Trisomy of the long arm of chromosome in a patient with primary myelofibrosis during blast crisis]. / Die Trisomie des langen Armes des ersten Chromosoms bei einem Patienten mit primärer Myelofibrose während der Blastenkrise.

The caryotype of a patient't leukemic cells with primary myelofibrosis being at the stage of blast crisis is described. In all cells examined a great submetacentric chromosome was detected which was formed by the duplication of the whole long arm of the first chromosome. The second chromosome of the first pair remained unchanged. Moreover, there was no sexual chromosome Y in seven metaphase plates. The significance of these and other changes of the first chromosome in the genesis of some malign diseases is discussed.