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1.
Am J Obstet Gynecol ; 200(3): 318.e1-6, 2009 Mar.
Article in English | MEDLINE | ID: mdl-19110232

ABSTRACT

OBJECTIVE: We sought to use magnetic resonance (MR) imaging (MRI) to estimate percentage of fetal thorax occupied by lung, liver, and other abdominal organs in pregnancies with congenital diaphragmatic hernia (CDH). STUDY DESIGN: This was a retrospective study of pregnancies with isolated CDH referred for MRI between August 2000 and June 2006. Four regions of interest were measured in the axial plane by an investigator blinded to neonatal outcome, and volumes were then calculated. The percentages of thorax occupied by lung, liver, and all herniated organs were then compared with neonatal outcomes. RESULTS: Fifteen CDH fetuses underwent MRI at a median gestational age of 29 weeks. Liver herniation was found in 93%. When the liver occupied > 20% of the fetal thorax, neonatal deaths were significantly increased. Percentages of lung and other herniated organs were not associated with outcome. CONCLUSION: In our MR series of isolated CDH, neonatal deaths were significantly increased when > 20% of the fetal thorax was occupied by liver.


Subject(s)
Hernia, Diaphragmatic/pathology , Hernia/pathology , Magnetic Resonance Imaging , Pregnancy Outcome , Prenatal Diagnosis/methods , Aristolochia , Female , Fetal Death/pathology , Hernia/congenital , Hernia/mortality , Hernia, Diaphragmatic/mortality , Hernias, Diaphragmatic, Congenital , Humans , Infant, Newborn , Liver/pathology , Predictive Value of Tests , Pregnancy , Pregnancy Complications/mortality , Pregnancy Complications/pathology , Prenatal Diagnosis/instrumentation , Prognosis , Retrospective Studies
2.
Obstet Gynecol ; 110(3): 663-8, 2007 Sep.
Article in English | MEDLINE | ID: mdl-17766615

ABSTRACT

OBJECTIVE: To describe pregnancy outcomes with fetal gastroschisis, including the associations of prenatal ultrasound findings with neonatal surgical complications and other morbidities. METHODS: This was a review of pregnancies complicated by fetal gastroschisis and delivered from January 1998 through June 2006. The last ultrasonogram before delivery was reviewed to determine stomach dilatation, bowel dilatation, or abnormalities of amniotic fluid volume. Neonatal records were reviewed to determine type of closure and any bowel complications. RESULTS: There were 66 pregnancies with gastroschisis, 1 per 2,000 deliveries. There were three stillbirths and three neonatal deaths. Delayed closure was necessary in 49% who underwent surgery. Birth weight below the third percentile, which occurred in 38%, was associated with need for delayed closure, 64% compared with 25% without growth restriction, P<.001, but was not associated with longer hospital stay or neonatal death. Fetal gastroschisis was diagnosed by prenatal ultrasonography in 58 cases. Bowel complications requiring surgery were more frequent when ultrasonography had demonstrated stomach dilatation (five cases), 60% compared with 10%, P=.002. Fetuses with defects so large that no normal ventral wall could be visualized ultrasonographically (three cases) were at increased risk for neonatal death, 100% compared with 0%, P<.001. CONCLUSION: Ultrasound findings associated with adverse outcome in fetal gastroschisis included stomach dilatation and a defect so large that no normal ventral wall could be visualized. Fetal growth restriction was common, and such infants were more likely to require delayed gastroschisis closure. Despite more than 90% survival, morbidity with gastroschisis remains high. LEVEL OF EVIDENCE: II.


Subject(s)
Fetal Diseases/diagnostic imaging , Gastroschisis/diagnostic imaging , Infant Mortality , Pregnancy Outcome , Ultrasonography, Prenatal/methods , Abdominal Wall/abnormalities , Abdominal Wall/diagnostic imaging , Adult , Female , Fetal Diseases/diagnosis , Fetal Diseases/mortality , Fetal Diseases/surgery , Fetal Growth Retardation/epidemiology , Gastric Dilatation/diagnosis , Gastric Dilatation/diagnostic imaging , Gastric Dilatation/mortality , Gastric Dilatation/surgery , Gastroschisis/diagnosis , Gastroschisis/mortality , Gastroschisis/surgery , Humans , Infant, Newborn , Length of Stay , Male , Pregnancy , Risk Assessment , Stillbirth/epidemiology , Treatment Outcome
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