ABSTRACT
The total synthesis of noricumazole B, a secondary metabolite from myxobacteria, was achieved. It established the glycan moiety to be D-α-arabinoside.
Subject(s)
Arabinose/chemistry , Isocoumarins/chemical synthesis , Oxazoles/chemical synthesis , Isocoumarins/chemistry , Molecular Structure , Myxococcales/chemistry , Myxococcales/metabolism , Oxazoles/chemistryABSTRACT
The total synthesis of 16 new ion channel inhibitors derived from noricumazoleâ A, a secondary metabolite from the myxobacterium Sorangium cellulosum, is reported. Particular focus of library design is put on stereochemical permutations in the central region (C9 and C11), the oxazole moiety and the side chain at C4 of the isochromanone moiety. Noricumazoleâ A and all new noricumazole derivatives were tested in an assay system with inhibitory effect on the hepatitisâ C virus (HCV) life cycle. Most of them are moderate to strong HCV inhibitors (350â nM-6â nM) but also exert pronounced cytotoxicity. In contrast, the thiazole analogue of noricumazoleâ A is a strong HCV inhibitor with only moderate cytotoxic property. It may become a lead structure with a good therapeutic index (CC(50)/IC(50)) of greater than 10.