Prevalence and heritability of psoriasis and benign migratory glossitis in one Brazilian population

Abstract: Background: An oral condition associated to psoriasis is benign migratory glossitis. The review of the literature does not show any publication about heritability in both soriasis and benign migratory glossitis and prevalence of psoriasis in the Brazilian population. Objective: This research was carried out in order to determine the prevalence of psoriasis and benign migratory glossitis in the Brazilian population from a Brazilian sample, as well as the heritability in these conditions. Methods: Six thousand patients were studied from the records of the outpatient dermatology department. The sample had 129 patients with cutaneous psoriasis, 399 with benign migratory glossitis without psoriasis and a control group with 5,472 patients. After data collection, the statistical analysis was made using Woolf, Chi-square and Falconer tests. Results: The prevalence of psoriasis was 2.15% and the benign migratory glossitis was 7.0%. The prevalence of benign migratory glossitis in the psoriasis group was high (16.3%), and that was statistically significant. Family history in the psoriasis group was 38% for the condition itself and 2,75% for benign migratory glossitis and in the benign migratory glossitis group was 17.54% for the condition itself and 1.5% for psoriasis. The study of heritability was 38.8% for psoriasis and 36.6% for benign migratory glossitis, both with medium heritability. Study limitations: This study was only in the state of São Paulo. Conclusion: This is the first publication that quantifies how much of these conditions have a genetic background and how important the environmental factors are in triggering them.

Prevalence and heritability of psoriasis and benign migratory glossitis in one Brazilian population.

BACKGROUND: An oral condition associated to psoriasis is benign migratory glossitis. The review of the literature does not show any publication about heritability in both soriasis and benign migratory glossitis and prevalence of psoriasis in the Brazilian population. OBJECTIVE: This research was carried out in order to determine the prevalence of psoriasis and benign migratory glossitis in the Brazilian population from a Brazilian sample, as well as the heritability in these conditions. METHODS: Six thousand patients were studied from the records of the outpatient dermatology department. The sample had 129 patients with cutaneous psoriasis, 399 with benign migratory glossitis without psoriasis and a control group with 5,472 patients. After data collection, the statistical analysis was made using Woolf, Chi-square and Falconer tests. RESULTS: The prevalence of psoriasis was 2.15% and the benign migratory glossitis was 7.0%. The prevalence of benign migratory glossitis in the psoriasis group was high (16.3%), and that was statistically significant. Family history in the psoriasis group was 38% for the condition itself and 2,75% for benign migratory glossitis and in the benign migratory glossitis group was 17.54% for the condition itself and 1.5% for psoriasis. The study of heritability was 38.8% for psoriasis and 36.6% for benign migratory glossitis, both with medium heritability. STUDY LIMITATIONS: This study was only in the state of São Paulo. CONCLUSION: This is the first publication that quantifies how much of these conditions have a genetic background and how important the environmental factors are in triggering them.

Perfil clínico-epidemiológico da genética médica no Sistema Único de Saúde: análise do município de São Carlos, SP / Clinical and epidemiological profile of medical genetcs in the single health system: analysis of the city of São Carlos, SP

Doenças genéticas afetam entre 3% a 7% da população mundial. Além disso,doenças genéticas e anomalias congênitas representam a segunda causa de mortalidade infantil no Brasil. Reconhecendo isto, em junho de 2006, foi reativado o Ambulatório de Genética Médica no município de São Carlos, SP, por meio de parceria entre a Secretaria Municipal de Saúde e a Universidade Federal de São Carlos, como um serviço de integração docente-assistencial. O Ambulatório está inserido no SUS e atende a população do município e microrregião, o que totaliza aproximadamente 240.000 pessoas. O objetivo deste estudo foi conhecer o perfil clínico-epidemiológico dos pacientes atendidos, no período entre junho de 2006 e dezembro de 2009. Trata-se de estudo transversal, realizado por meio de revisãopadronizada dos prontuários dos pacientes. Foram atendidos 317 pacientes, 172 (54,26%) dos quais do sexo feminino e 12 (3,79%) aparentados. A idade variou de14 dias de vida a 73 anos (média de 11 anos e 7 meses, desvio padrão de ± 19 anos e 5 meses). Deficiência mental e baixa estatura foram os motivos mais frequentes para encaminhamento. Cento e vinte um pacientes (38,17%) receberam diagnóstico de doenças genéticas ou anomalias congênitas. Com relação à resolutibilidade, 104 pacientes (32,81%) receberam alta, 161 (50,79%) continuaram em seguimento clínico e 52 (16,40%) foram encaminhados paraserviços de genética de maior complexidade. Os resultados endossam a necessidade de consolidação de uma rede de cuidado integral, inserida no SUS, que atenda os pacientes com doenças genéticas e anomalias congênitas em todos os níveis da atenção à saúde, com ênfase na prevenção da deficiência mental

Analysis of mixture in the distributions of immunoglobulin levels in a chagasic population

Os componentes das distribuiçöes dos níveis séricos de IgA, IgG e IgM foram investigados em uma amostra de cerca de 300 pessoas, habitantes de uma regiäo brasileira onde a doença de Chagas é endêmica. As distribuiçöes de IgG e IgM parecem ser compostas de 2 componentes, ambos assimétricos; a distribuiçäo de IgA é composta de apenas um componente. Estes resultados sugerem a açäo de um gene principal ou de um evento ambiental discreto sobre as distribuiçöes de IgG e IgM. Por sua vez, a distribuiçäo de IgA seria determinada por componentes multifatoriais