Body mass index and mortality among community-dwelling elderly of Southern Brazil.

This study aims to measure the association between body mass index (BMI), comparing two different classifications, and mortality among community-dwelling elderly considering myopenia in Pelotas, Brazil. This is a longitudinal study started in 2014, we followed 1451 elderly people (≥ 60 years) enrolled in the "COMO VAI?" study. BMI was classified according to the World Health Organization (WHO) and the classification with specific cutoff points for older adults. Myopenia was measured by calf circumference (≤33 cm for women and ≤34 cm for men). Cox proportional-hazards models were used to test associations controlling for sociodemographic and behavioral characteristics and number of morbidities. Nearly 10% (N = 145) of the elderly died during almost three years of follow-up. We observed a L-shaped relation between BMI and mortality. Elderly with underweight had a higher mortality risk compared to those with adequate BMI in both classifications. According to the WHO classification, overweight elderly presented protection for mortality (HR: 0.58; 95% CI 0.38-0.87) when compared to those with adequate BMI. Among elderly with myopenia, overweight by WHO continued to protect against mortality, although not significantly, while those with the specific classification underweight presented a higher risk of death compared to those with normal weight (HR: 2.09; 95% CI 1.06-4.14). In conclusion the underweight increased the risk of death in community-dwelling elderly people during a follow-up of three years. The specific classification seemed to be more adequate to indicate risk of mortality in this population. Higher BMI protect against mortality when muscle mass was not considered.

Strength and multimorbidity among community-dwelling elderly from southern Brazil.

OBJECTIVE: The number of chronic diseases is associated with the reduction in muscle mass and strength in older people (≥60 y of age). The purpose of this study was to asses the association between multimorbidities and handgrip strength in older community-dwelling individuals from a city in southern Brazil, identifying potential differences according to sex and loss of muscle mass. METHODS: This was a cross-sectional population-based study among older individuals living in the urban area of Pelotas, Rio Grande do Sul, Brazil. Grip strength was assessed with digital dynamometers according to the criteria of the European Working Group on Sarcopenia in Older People (EWGSOP) to define dynapenia. Multimorbidity was defined by self-report as the presence of at least 5 diseases diagnosed by a physician. Covariates of the study were age, sex, socioeconomic status, schooling, marital status, nutritional status, alcohol consumption, and smoking habits. Statistical analyses were stratified according to the presence of myopenia (low muscle mass). RESULTS: We received completed information from 1336 individuals ≥60 y of age. Multimorbidity was 50% and 16% more prevalent, respectively, among men and women classified in the lower quartile of manual grip strength (prevalence ratio [PR], 1.50; 95% confidence interval [CI], 1.15-1.95 for men and PR, 1.16; 95% CI, 1.03-1.32 for women) compared with those from the upper quartile. Among men without myopenia, the presence of dynapenia increased the odds of having multimorbidity (PR, 1.42; 95% CI, 1.18-1.71). Among those with myopenia, there was a 10% increase in the prevalence of multimorbidity only for women with dynapenia (PR, 1.10; 95% CI, 1.00-1.21). CONCLUSION: Results from the present study indicated an association between manual grip strength and multimorbidity among this population, and the effect measures were greater in men. Manual grip strength proved to be a good marker of health in this population, especially in those who did not present with myopenia.

Sarcopenia as a mortality predictor in community-dwelling older adults: a comparison of the diagnostic criteria of the European Working Group on Sarcopenia in Older People.

BACKGROUND/OBJECTIVES: The definition of sarcopenia remains a matter of discussion and there is no globally accepted consensus for its diagnosis. The aim of this study was to assess the effect of sarcopenia diagnostic components on mortality, as well as to compare the associations between sarcopenia diagnosed via the 2010 and 2018 Consensuses of the European Working Group on Sarcopenia in Older People (EWGSOP) and mortality. METHODS: Prospective cohort study involving noninstitutionalized older adults aged ≥ 60 years. For the diagnosis of sarcopenia, the definitions proposed by the 2010 (EWGSOP) and 2018 (EWGSOP2) Consensuses were used. The diagnostic components corresponded to muscle mass, muscular strength, and physical performance. The associations of sarcopenia and its components with mortality were investigated using Cox proportional hazard regression models. RESULTS: The sample consisted of 1291 older adults. After an average of 2.6 years of follow-up, 88 (6.8%) participants had died. The diagnosis of severe sarcopenia by both Consensuses was associated with an increased risk of mortality. Severe sarcopenia was associated with an increased risk of death compared with that in people without sarcopenia when using EWGSOP (hazard ratio (HR) 3.15, 95% confidence interval (CI) 1.44-6.90) and EWGSOP2 (HR 4.11, 95% CI 1.88-9.00). Older adults with decreased gait speed had a 76% higher risk of dying (p = 0.033). There was no statistically significant association between the other sarcopenia components and mortality risk. CONCLUSIONS: Older adults with severe sarcopenia and those with changes in physical performance had an increased risk of death in the short term.

Tipos de atividades físicas e densidade mineral óssea em adultos aparentemente saudáveis / Types of physical activity and bone mineral density in apparently healthy adults

Introdução: O tipo de atividade física (AF) pode influenciar a relação entre esta e a densidade mineral óssea (DMO). Desta forma, o objetivo do presente estudo é avaliar a relação entre diferentes tipos de AF e DMO em adultos. Método: Estudo transversal realizado com amostra de conveniência (n=208 indivíduos de 20 a 59 anos) de Pelotas, RS. A DMO (g/cm2) foi avaliada por absorciometria de raios-X de dupla energia (DXA) e a prática de caminhada e AF de intensidades moderada e vigorosa no lazer foram avaliadas por meio da respectiva seção da versão longa do Questionário Internacional de Atividade Física (IPAQ). A associação entre a DMO e os diferentes tipos de AF foi avaliada por regressão linear. Resultados: Em torno de 67% dos participantes atendiam à recomendação de ≥150 min/sem de AF. Não houve diferença estatisticamente significativa nas medidas da DMO entre indivíduos com maior ou menor tempo semanal em prática de caminhada, AF de intensidade moderada e vigorosa, isoladamente. Porém, foi observado um aumento, com margem inferior do intervalo de confiança no limite da significância, na DMO de indivíduos do segundo tercil de tempo gasto em AF total ­ 160-300 min/sem (ß=0,025 IC95%=0,001; 0,049), quando comparados ao grupo menos ativo. Conclusão: O estudo não encontrou associação entre DMO e a prática de caminhada e AF de intensidade moderada e vigorosa, podendo haver uma relação com o total acumulado de AF por semana, entre indivíduos que atendem à recomendação de AF, mas não são altamente ativos.(AU)

Introduction: Type of physical activity (PA) can influence the relationship between it and bone mineral density (BMD). Thus, the aim of the current study is evaluate the relationship between different types of PA and BMD in adults. Methods: Cross-sectional study using a convenience sample (n=208 individuals from 20 to 59 years old) in Pelotas, RS. BMD (g/cm2) was measured by dual energy X-ray absorptiometry (DXA) and time spent in walking and moderate and vigorous PA during the leisure-time was evaluated by the International Physical Activity Questionnaire in the long version. Association between BMD and types of PA was evaluated by linear regression analyses. Results: About 67% out of the subjects reached the recommendation of ≥150 min/week of PA during the leisure-time. There was no statistically significant difference in the BMD among individuals with higher or lower weekly time spent in walking, moderate or vigorous PA. However, a slightly difference was observed in BMD from subjects in the second tertile of time spent in any activity ­ 160-300 min/week (ß=0.025 IC95%=0.001; 0.049), in comparison to individuals in the first tertile of PA. Conclusion: There was no statistical association of walking, moderate and vigorous PA alone with BMD. It is possible a relationship between the total amount weekly spent in any PA in individuals who reached the PA recommendation but were not highly active.(AU)

Enhancing SARC-F: Improving Sarcopenia Screening in the Clinical Practice.

OBJECTIVES: To validate the (Brazilian) Portuguese-translated version of the SARC-F questionnaire and to verify its performance in the separate sarcopenia screening and muscle function evaluation contexts. In addition, by associating SARC-F to an anthropometric measurement (as an estimate of muscle mass), to test for improvements in its sarcopenia screening efficacy. DESIGN: Cross-sectional study. SETTING: Urban population of Pelotas, a middle-sized city in Southern Brazil. PARTICIPANTS: Subsample of 179 community-dwelling elderly aged 60 years or older derived from a population-based study (COMO VAI?). MEASUREMENTS: Sarcopenia was evaluated using the European Working Group on Sarcopenia in Older People's diagnostic criteria: dual-energy X-ray absorptiometry, handgrip strength, and walking speed test. Participants also completed SARC-F and their calf circumference (CC) was measured. SARC-F and CC were combined into an original score. The questionnaires' performances were evaluated through receiver operating characteristic curves, sensitivity/specificity analyses, and Pearson χ2. RESULTS: Sarcopenia was identified in 15 (8.4%) participants by the European Working Group on Sarcopenia in Older People's criteria. Areas under the receiver operating characteristic curves of SARC-F were 0.592 (95% confidence interval (CI) 0.445, 0.739) screening for sarcopenia and 0.779 (95% CI 0.710, 0.846) evaluating muscle function (P < .001). The SARC-F+CC association significantly improved SARC-F's sarcopenia screening performance [area under the curve: 0.736 (95% CI 0.575, 0.897); comparing with SARC-F alone: P = .027]. A substantial improvement in sensitivity was achieved without compromising the remaining parameters. CONCLUSIONS: Despite the satisfactory performance evaluating muscle function, SARC-F alone has not achieved adequate results as a sarcopenia screening tool. However, the SARC-F+CC association significantly improved SARC-F's sarcopenia screening performance, enabling its use in the clinical practice.

Estimation of body fat in adults using a portable A-mode ultrasound.

OBJECTIVE: This study aimed to develop and validate equations to estimate body fat based on anthropometric measurements of subcutaneous fat thickness (SFT) and muscle thickness (MT) measured by A-mode ultrasound (BodyMetrix) in Brazilian adults. METHODS: Individuals (n = 206) underwent air-displacement plethysmography for body composition assessment. Arm, thigh, and calf circumferences were also obtained. SFT from triceps, biceps, subscapular, abdominal, thigh, and calf regions and MT from triceps, biceps, thigh, and calf regions were measured by BodyMetrix. Prediction equations were developed by stepwise multiple linear regression using the circumferences, weight, height, SFT, and MT. Lin's concordance correlation coefficient, mean difference, and 95% limits of agreement (95% LOA) were assessed in apparent and internal validity. RESULTS: The prediction equation for whole-body fat for men included thigh circumference, triceps and thigh SFT, biceps MT, weight, and height. The equation for women included age, calf circumference, abdominal and calf SFT, weight, and height. The prediction equation overestimated men's whole-body fat by 0.5 percentual points, in average, and the lower and upper 95% LOA were -6.8% and 7.7%, respectively. For women, the prediction equation overestimated whole-body fat by 0.1 percentual points, in average. Lower and upper 95% LOA were -6.5% and 6.7%, respectively. Optimism-adjusted results using 500 repetitions with same size samples have shown similar results. Body fat extremes did not influence the whole-body fat estimation. CONCLUSIONS: BodyMetrix A-mode ultrasound, in association with selected conventional anthropometric measurements, proved to be a reliable tool for the estimation of body fat percentage.

Is adductor pollicis muscle thickness a good predictor of lean mass in adults?

BACKGROUND & AIMS: Lean mass (LM) is an important parameter in clinical outcomes, which highlights the necessity of reliable tools for its estimation. The adductor pollicis muscle thickness (APMT) is easily accessible and suffers minimal interference from the adjacent subcutaneous fat tissue. OBJECTIVE: To assess the relationship between the APMT and LM in a sample of Southern Brazilian adults. METHODS: Participants were adults from the 1982 Pelotas (Brazil) Birth Cohort. LM was measured by dual energy X-ray absorptiometry (DXA). LM and lean mass index (LMI - LM divided by the square of height - kg/m(2)) were the outcomes. APMT was measured using a skinfold caliper. The mean of three measurements in the non-dominant hand was used in the analyses. APMT was described according to socio-demographic characteristics and nutritional status. The relationship between APMT and both LM and LMI was evaluated by correlation coefficient and linear regression using APMT as a single anthropometric parameter and also in addition to BMI. RESULTS: APMT was assessed in 3485 participants. APMT was higher in males, non-whites, less-schooled and obese individuals. APMT was moderately correlated to LM and LMI (ranged from 0.44 to 0.57). Correlation coefficients were higher for LMI as outcome and in females (LM: 0.51 and LMI: 0.57). APMT explained 19% and 26% of the variance in LM in males and females, respectively, whereas it explained 26% and 33% of the variance in LMI. APMT increased the prediction for LM in 3 and 4 percentage points in males and females, in comparison to explained by BMI. BMI explained 48% and 59% of the variance of LMI in males and females whereas APMT increased it to 51% and 62% for both sexes, respectively. CONCLUSIONS: Results were not good enough to promote the APMT as a single predictor of LM or LMI in epidemiological studies. APMT has a little predictive capacity in estimating LM or LMI when BMI is also considered.

Adductor pollicis muscle: A study about its use as a nutritional parameter in surgical patients.

BACKGROUND & AIMS: Body composition is important to identify malnutrition, and several anthropometric measurements are used to estimate muscle mass in the clinical practice. This study aimed to assess the adductor pollicis muscle thickness (APMT), its covariates and association with malnutrition in hospitalized surgical patients. METHODS: APMT was measured in 361 surgical patients in both dominant (DAPMT) and non-dominant (NDAPMT) sides. APMT values below the 5th percentile of reference values provided by a healthy population were considered as malnourished. Nutritional status was assessed by Subjective Global Assessment (SGA). The difference in APMT values among nutritional status categories was evaluated, and the association between malnutrition by SGA and APMT was estimated using multivariate linear regression. Sensitivity, specificity and positive and negative predictive values were also calculated. RESULTS: Most patients were women (60.4%). APMT values were significantly different among SGA categories. Well-nourished patients had APMT values significantly higher compared to the ones with moderate or severe malnutrition by SGA, with no significant difference between APMT values in moderate or severe malnourished patients. Statistically significant associations between both DAPMT and NDAPMT below the 5th percentile and malnutrition and were found (RR = 3.99, CI 95% = 3.19-5.00; p < 0.001; and RR = 3.92; CI 95% = 3.10-4.96; p < 0.001; respectively). Gender, age, estimated weight and nutritional status were considered associated factors for APMT. APMT showed low sensitivity (DAPMT: 34.9%, NDAPMT: 37.7%) but high specificity (DAPMT: 98.7%, NDAPMT: 97.8%) to identify malnutrition. CONCLUSIONS: APMT was significantly associated with nutritional status in a sample of surgical patients. The APMT seems to be a simple and useful anthropometric tool to confirm the diagnosis of malnutrition.