1.
Beilstein J Org Chem
; 10: 2903-11, 2014.
Article
in English
| MEDLINE
| ID: mdl-25550757
ABSTRACT
Fluconazole was studied with two different hydrophilic cyclodextrins (hydroxypropyl-ß-cyclodextrin (HPBCD) and sulfobutyl ether-ß-cyclodextrin (SBECD)) for the formation of inclusion complexes. HPBCD and SBECD showed low cell cytotoxicity in human keratocytes as assessed by the label-free xCELLigence system for real-time monitoring. The fluconazole-HPBCD complex was incorporated into an ion-sensitive ophthalmic gel composed of the natural polysaccharides gellan gum and κ-carrageenan. This system showed good bioadhesive properties and effective control of fluconazole release.
2.
Retina
; 26(9): 1100, 2006.
Article
in English
| MEDLINE
| ID: mdl-17151509