[Levels of the C 4 component of the complement, lactoferrin and leukocytic thermostabile alpha glycoprotein during the treatment of patients with systemic rheumatic diseases]. / Dinamika soderzhaniia C4-komponenta komplementa, laktoferrina i leikotsitarnogo termostabi'lnogo alpha-glikoproteina v protsesse lecheniia bo'lnykh revmaticheskimi zabolevaniiami.

The authors studied the dynamics of C4-component of complement (C4), lactoferrin (LF), leukocytic thermostable alpha-glycoprotein (LT alpha G) in the blood serum of 54 patients with rheumatoid arthritis, 32 patients with systemic lupus erythematosus, 8 patients with systemic vasculitis under the effect of hemosorption (HS), enterosorption (ES) and also immunosuppressants (IS). In severe forms of systemic rheumatic diseases the blood serum exhibits a decreased content of C4 but an elevated level of LF and LT alpha G. It has been established that HS is more active than ES or IS, and it influences the mechanisms of humoral immunity. This finds its expression in normalization of C4 level. The favourable clinical effect of HS correlates with a decrease in the level of LF and LT alpha G in the blood serum of patients during treatment.

[Clinico-immunologic analysis of sorption methods of treatment of rheumatoid arthritis and systemic lupus erythematosus]. / Klinicho-immunologicheskii analiz sorbtsionnykh metodov lecheniia revmatoidnogo artrita i sistemnoi krasnoi volchanki.

The paper is concerned with the results of the application of the sorption methods for the treatment of patients with rheumatoid arthritis and systemic lupus erythematosus. The authors show the advisability of the use of the above methods for different variants of the disease course, define the time of the treatment and complications common to the sorption methods of the treatment. The results of the treatment by hemoperfusion and enterosorption are compared with the results of the patients' treatment with immunodepressants. A study was made of the action of the sorption methods and immunodepressants on the blood content of the main autoantigens and autoantibodies capable of participation in the forming of the immune complexes. The concentration and the qualitative composition of the circulating immune complexes were studied in the course of the treatment.