1.
J Med Chem
; 23(3): 313-9, 1980 Mar.
Article
in English
| MEDLINE
| ID: mdl-7365748
ABSTRACT
We have shown previously that the esters of adenosine-5'-carboxylic acid (10) represent a new class of potent nontoxic coronary vasodilators. For example, the ethyl ester (12), which is active by an intraduodenal or intravenous route in dogs, causes a large increase in coronary sinus PO2 and coronary blood flow. Because of the pronounced vasoactive properties of the esters of adenosine-5'-carboxylic acid, a systematic study of the corresponding amides (14--50) was undertaken. In addition, several other analogues containing the N1-oxide function (51--52) or 2',3' substituents (3--9, 53--54) were studied.
Subject(s)
Adenosine/analogs & derivatives , Hemodynamics/drug effects , Adenosine/chemical synthesis , Adenosine/pharmacology , Adenosine/toxicity , Animals , Female , Lethal Dose 50 , Male , Mice , Molecular Conformation , Structure-Activity Relationship
2.
J Med Chem
; 14(6): 543-5, 1971 Jun.
Article
in English
| MEDLINE
| ID: mdl-5091971
Subject(s)
Vasodilator Agents , Xanthines , Animals , Blood Pressure/drug effects , Dogs , Heart Rate/drug effects , Partial Pressure , Piperazines/pharmacology , Theophylline , Vasodilator Agents/chemical synthesis , Vasodilator Agents/pharmacology , Xanthines/chemical synthesis , Xanthines/pharmacology
3.
J Med Chem
; 14(4): 372-3, 1971 Apr.
Article
in English
| MEDLINE
| ID: mdl-5553757
4.
J Med Chem
; 13(3): 544-6, 1970 May.
Article
in English
| MEDLINE
| ID: mdl-5441140
5.
J Med Chem
; 12(5): 927-8, 1969 Sep.
Article
in English
| MEDLINE
| ID: mdl-5812222