ABSTRACT
The female genital tract is an infrequent site of metastasis, in particular from extragenital primary tumors such as non-small cell lung cancer. Ovarian metastases have been described as disseminations of lung adenocarcinoma; rare cases of secondary localizations in adnexa, cervix and vagina were also observed in the literature, but none of these had endometrial involvement. We report the first case, to our knowledge, of non-small cell lung cancer with metastatic spread to the endometrium.
Subject(s)
Adenocarcinoma/secondary , Bone Neoplasms/secondary , Carcinoma, Non-Small-Cell Lung/secondary , Endometrial Neoplasms/secondary , Endometrium/pathology , Lung Neoplasms/pathology , Adenocarcinoma/chemistry , Adenocarcinoma/diagnostic imaging , Adenocarcinoma/pathology , Adenocarcinoma of Lung , Biomarkers, Tumor/analysis , Bone Neoplasms/chemistry , Carcinoma, Non-Small-Cell Lung/chemistry , DNA-Binding Proteins/analysis , Endometrial Neoplasms/chemistry , Female , Humans , Immunohistochemistry , Lung Neoplasms/chemistry , Lung Neoplasms/diagnostic imaging , Middle Aged , Tomography, X-Ray Computed , Transcription FactorsABSTRACT
Neutropenic enterocolitis, or typhlitis, is an unusual acute complication of chemotherapy-induced neutropenia, characterized by inflammatory process involving colon and/or small bowel that may progress to necrosis, haemorrhage, perforation and septicaemia. Typhlitis is usually seen in the setting of severe chemotherapy-induced neutropenia for acute leukaemia. Nevertheless, it is increasingly recognized as a complication of therapy in solid tumors. We present a case of typhlitis in a patient with advanced non-small cell lung cancer (NSCLC) who received pemetrexed, as second-line chemotherapy treatment.
