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Genetic selection for susceptibility to oral tolerance leads to a profound reduction of the acute inflammatory response.
da Silva, Maria de Fátima Sarro; da Nóbrega, Alberto; Barja-Fidalgo, Tereza Cristina; Brando-Lima, Aline C; Cunha, Fernando; da Silva, Antonio Carlos.
Ann N Y Acad Sci ; 1029: 398-401, 2004 Dec.
Article in English | MEDLINE | ID: mdl-15681791

ABSTRACT

Strains of mice obtained by genetic selection to extremes of phenotype for susceptibility or resistance to oral tolerance were investigated for possible genetic correlations with acute inflammatory response using different models of inflammation. The results show a strong genetic association.


Subject(s)
Disease Susceptibility/immunology , Immunity, Mucosal , Inflammation/immunology , Mouth Mucosa/immunology , Acute Disease , Animals , Antigens/immunology , Immune Tolerance , Inflammation/prevention & control , Lipopolysaccharides/immunology , Lipopolysaccharides/toxicity , Mice , Ovalbumin/immunology
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