1.
Medchemcomm
; 6(10): 1761-1766, 2015 Oct 08.
Article
in English
| MEDLINE
| ID: mdl-26962429
ABSTRACT
N-Myristoyltransferase (NMT) is a potential drug target in Leishmania parasites. Scaffold-hopping from published inhibitors yielded the serendipitous discovery of a chemotype selective for Leishmania donovani NMT; development led to high affinity inhibitors with excellent ligand efficiency. The binding mode was characterised by crystallography and provides a structural rationale for selectivity.