ABSTRACT
Clinicophysiological survey of the children living in polluted ambient air areas has revealed the high incidence of cardiovascular functional, adaptative, and regulatory disorders at rest and after graded exercise.
Subject(s)
Air Pollution/adverse effects , Cardiovascular System/physiopathology , Adaptation, Physiological , Child , Child, Preschool , Heart Function Tests , Humans , Mitral Valve Prolapse/physiopathology , SiberiaABSTRACT
Interrelationship between the structure-and-function changes in feto-placental complex and the worsening health status and development of children in arms effected by the chemical pollution of the ambient air was shown. Feto-placental changes expressed in decreasing of the protein and nucleic acid content and increasing of membrane permeability.
Subject(s)
Air Pollutants/adverse effects , Embryonic and Fetal Development/drug effects , Fetal Growth Retardation/chemically induced , Infant, Newborn/physiology , Placenta/drug effects , Xenobiotics/adverse effects , Adolescent , Adult , Anthropometry , Apgar Score , Atrophy/chemically induced , Embryonic and Fetal Development/physiology , Female , Humans , Placenta/pathology , Placenta/physiopathology , Pregnancy , RussiaSubject(s)
Air Pollutants/toxicity , Lung/drug effects , Models, Biological , Respiration/drug effects , Animals , Histocytochemistry , Lung/cytology , Lung/metabolism , Male , Rabbits , Time FactorsABSTRACT
Metabolic shifts in the myocardium under conditions of long-term exposure of the body to air pollution were studied in experiments on albino rats. Study of the content of protein, RNA, DNA, glycogen, ATP, lactic and pyruvic acids and the activity of lactate dehydrogenase and creatine kinase in the heart muscle allowed the conclusion that the glycolytic processes are intensified, the bioenergic processes are inhibited and the synthesis of protein and RNA are increased in the myocardium of the experimental animals.