1.
Bioorg Med Chem
; 16(15): 7218-24, 2008 Aug 01.
Article
in English
| MEDLINE
| ID: mdl-18656370
ABSTRACT
A series of pyrrolobenzodiazepine-naphthalimide conjugates tethered through a piperazine ring system have been designed, synthesized, and evaluated for their anticancer activity. These new conjugates exhibit very high DNA binding affinity and cytotoxic activity against a number of cell lines.
Subject(s)
Antineoplastic Agents/chemistry , Antineoplastic Agents/pharmacology , DNA/chemistry , Naphthalimides/chemistry , Naphthalimides/pharmacology , Cell Line, Tumor , Dose-Response Relationship, Drug , Humans , Molecular Structure , Nucleic Acid Denaturation , Structure-Activity Relationship
2.
Bioorg Med Chem
; 15(22): 6868-75, 2007 Nov 15.
Article
in English
| MEDLINE
| ID: mdl-17822905
ABSTRACT
A series of pyrrolo[2,1-c][1,4]benzodiazepine-anthraquinone conjugates have been prepared and evaluated for their DNA binding ability as well as anticancer activity. Some of these molecules have shown significant anticancer activity in a number of cancer cell lines.