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Adv Sci (Weinh) ; 11(20): e2307060, 2024 May.
Article in English | MEDLINE | ID: mdl-38516744

ABSTRACT

Biodegradable nanomaterials can significantly improve the safety profile of nanomedicine. Germanium nanoparticles (Ge NPs) with a safe biodegradation pathway are developed as efficient photothermal converters for biomedical applications. Ge NPs synthesized by femtosecond-laser ablation in liquids rapidly dissolve in physiological-like environment through the oxidation mechanism. The biodegradation of Ge nanoparticles is preserved in tumor cells in vitro and in normal tissues in mice with a half-life as short as 3.5 days. Biocompatibility of Ge NPs is confirmed in vivo by hematological, biochemical, and histological analyses. Strong optical absorption of Ge in the near-infrared spectral range enables photothermal treatment of engrafted tumors in vivo, following intravenous injection of Ge NPs. The photothermal therapy results in a 3.9-fold reduction of the EMT6/P adenocarcinoma tumor growth with significant prolongation of the mice survival. Excellent mass-extinction of Ge NPs (7.9 L g-1 cm-1 at 808 nm) enables photoacoustic imaging of bones and tumors, following intravenous and intratumoral administrations of the nanomaterial. As such, strongly absorbing near-infrared-light biodegradable Ge nanomaterial holds promise for advanced theranostics.


Subject(s)
Germanium , Photoacoustic Techniques , Phototherapy , Animals , Mice , Photoacoustic Techniques/methods , Germanium/chemistry , Phototherapy/methods , Disease Models, Animal , Lasers , Nanoparticles/chemistry , Metal Nanoparticles/chemistry , Metal Nanoparticles/therapeutic use , Biocompatible Materials/chemistry , Cell Line, Tumor , Neoplasms/therapy , Neoplasms/diagnostic imaging , Female
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