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Probl Tuberk Bolezn Legk ; (5): 27-31, 2009.
Article in Russian | MEDLINE | ID: mdl-19565809

ABSTRACT

Seventy-eight patients, aged 15.69 +/- 0.15 years, who had infiltrative pulmonary tuberculosis, were examined. Roncoleukin was given intravenously in 20 patients of them (Subgroup 1a), in an indirect lymphotropic fashion in 30 patients (Subgroup 1b); 28 adolescents were treated with the conventional treatments (Group 2). A decay phase was recorded in 33 (66%) from Group 1 and in 16 (57.1%) from Group 2. On admission, all 78 (100%) patients had immunological disorders that required immunomodulation. Roncoleukin caused positive clinical and X-ray changes that were more pronounced in Subgroup 1b: bacterial excretion cessation was recorded in 100% of patients in Subgroup 1a (p < 0.05); in 94.4% in Subgroup 1b (p < 0.05), and in 68.7% in Group 2; decay cavities closed in 69.2, 60, and 37.5% in Subgroups 1a and 1b and Group 2. At the same time, the duration of a procedure considerably reduced, which positively affected adolescents' compliance.


Subject(s)
Antitubercular Agents/therapeutic use , Interleukins/administration & dosage , Tuberculosis, Pulmonary/drug therapy , Adolescent , B-Lymphocytes/immunology , Drug Therapy, Combination , Follow-Up Studies , Humans , Injections, Intravenous , Interleukins/therapeutic use , Prospective Studies , Recombinant Proteins , T-Lymphocytes/immunology , Time Factors , Treatment Outcome , Tuberculosis, Pulmonary/immunology
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