ABSTRACT
BACKGROUND: There are no guidelines to screen haemato-oncologic children when a tuberculosis (TB) outbreak is suspected. METHODS: After exposition to an adult with active TB, children exposed from a haemato-oncology unit were screened according to immunosuppression status and time of exposure. Until an evaluation after 8-12 weeks from last exposure, isoniazid was indicated to those with negative initial work-up. RESULTS: After 210 interventions, we detected a case of pulmonary TB, and another with latent TB infection. Pulmonary findings and treatment approach were challenging in some patients. CONCLUSIONS: The TB screening of oncologic children required a multidisciplinary approach, and clinicians managed challenging situations.
Subject(s)
Latent Tuberculosis , Tuberculosis , Adult , Antitubercular Agents/therapeutic use , Child , Humans , Isoniazid , Latent Tuberculosis/diagnosis , Prevalence , Tuberculosis/diagnosis , Tuberculosis/epidemiology , Tuberculosis/prevention & controlABSTRACT
Background: There are no guidelines to screen haemato-oncologic children when a tuberculosis (TB) outbreak is suspected. Methods: After exposition to an adult with active TB, children exposed from a haemato-oncology unit were screened according to immunosuppression status and time of exposure. Until an evaluation after 812 weeks from last exposure, isoniazid was indicated to those with negative initial work-up. Results: After 210 interventions, we detected a case of pulmonary TB, and another with latent TB infection. Pulmonary findings and treatment approach were challenging in some patients. Conclusions: The TB screening of oncologic children required a multidisciplinary approach, and clinicians managed challenging situations.(AU)
Antecedentes: No existen pautas para el cribado de niños hematooncológicos cuando se sospecha de un brote de tuberculosis (TB). Métodos: Después de la exposición a un adulto con TB activa, se evaluó a los niños expuestos de una unidad de hematooncología según el estado de inmunosupresión y el tiempo de exposición. Hasta una evaluación después de ocho a12 semanas desde la última exposición, se indicó isoniazida para aquellos con un proceso inicial negativo. Resultados: Tras 210 intervenciones se detectó un caso de tuberculosis pulmonar y otro con infección por TB latente. Los hallazgos pulmonares y el método de tratamiento fueron un desafío en algunos pacientes. Conclusiones: El cribado de TB en niños oncológicos requirió un método multidisciplinario y los médicos manejaron situaciones complejas.(AU)
Subject(s)
Humans , Child , Tuberculosis , Hematology , Medical Oncology , Pediatrics , Mass Screening , Immunosuppression Therapy , Isoniazid , Tuberculosis, Pulmonary , Microbiology , Communicable DiseasesABSTRACT
BACKGROUND: There are no guidelines to screen haemato-oncologic children when a tuberculosis (TB) outbreak is suspected. METHODS: After exposition to an adult with active TB, children exposed from a haemato-oncology unit were screened according to immunosuppression status and time of exposure. Until an evaluation after 8-12 weeks from last exposure, isoniazid was indicated to those with negative initial work-up. RESULTS: After 210 interventions, we detected a case of pulmonary TB, and another with latent TB infection. Pulmonary findings and treatment approach were challenging in some patients. CONCLUSIONS: The TB screening of oncologic children required a multidisciplinary approach, and clinicians managed challenging situations.
Subject(s)
Liver Neoplasms/complications , Neoplasms, Connective Tissue/pathology , Neoplasms, Germ Cell and Embryonal/complications , Sarcoma/complications , Adolescent , Combined Modality Therapy , Female , Humans , Liver Neoplasms/therapy , Neoplasms, Connective Tissue/drug therapy , Neoplasms, Connective Tissue/etiology , Neoplasms, Germ Cell and Embryonal/therapy , Osteomalacia , Paraneoplastic Syndromes , Prognosis , Sarcoma/therapyABSTRACT
No disponible
Subject(s)
Humans , Female , Child , Hemoglobin SC Disease/diagnosis , Musculoskeletal Pain/diagnosis , Hemoglobin SC Disease/pathology , Musculoskeletal Pain/etiology , RecurrenceABSTRACT
La histiocitosis de células de Langerhans es una enfermedad infrecuente en el lactante y su presentación como una adenitis cervical aislada sin otra sintomatología es excepcional en estos pacientes. Se describe el caso de una lactante de 3 meses de edad que presentaba una tumoración cervical en el ángulo mandibular derecho, con mala respuesta al tratamiento antibiótico. Se realizó una punción-aspiración con aguja fina, que confirmó el diagnóstico de histiocitosis de células de Langerhans. El estudio de extensión no mostró afectación sistémica. Debe considerarse la histiocitosis de células de Langerhans en el diagnóstico diferencial de una masa cervical subaguda de evolución tórpida en los lactantes de corta edad y se debe plantear la realización de una punción-aspiración con aguja fina de manera precoz para establecer el diagnóstico.
Langerhans cell histiocytosis in infants is a rare condition, and presentation as an isolated cervical adenitis is exceptional at this age. We describe the case of a 3-month-old female infant presenting with a neck mass in the right mandibular angle with poor response to antibiotic treatment. Fine needle aspiration was performed and confirmed the diagnosis of Langerhans cell histiocytosis with complementary tests showing no features of systemic involvement. Langerhans cell histiocytosis should be considered in the differential diagnosis of subacute neck masses with poor outcome in infants and physicians should consider performing a fine needle aspiration to establish the diagnosis.
Subject(s)
Humans , Female , Infant , Histiocytosis, Langerhans-Cell/diagnosis , Histiocytosis, Langerhans-Cell/complications , Lymphadenitis/etiology , NeckABSTRACT
Langerhans cell histiocytosis in infants is a rare condition, and presentation as an isolated cervical adenitis is exceptional at this age. We describe the case of a 3-month-old female infant presenting with a neck mass in the right mandibular angle with poor response to antibiotic treatment. Fine needle aspiration was performed and confirmed the diagnosis of Langerhans cell histiocytosis with complementary tests showing no features of systemic involvement. Langerhans cell histiocytosis should be considered in the differential diagnosis of subacute neck masses with poor outcome in infants and physicians should consider performing a fine needle aspiration to establish the diagnosis.
La histiocitosis de células de Langerhans es una enfermedad infrecuente en el lactante y su presentación como una adenitis cervical aislada sin otra sintomatología es excepcional en estos pacientes. Se describe el caso de una lactante de 3 meses de edad que presentaba una tumoración cervical en el ángulo mandibular derecho, con mala respuesta al tratamiento antibiótico. Se realizó una punción-aspiración con aguja fina, que confirmó el diagnóstico de histiocitosis de células de Langerhans. El estudio de extensión no mostró afectación sistémica. Debe considerarse la histiocitosis de células de Langerhans en el diagnóstico diferencial de una masa cervical subaguda de evolución tórpida en los lactantes de corta edad y se debe plantear la realización de una punción-aspiración con aguja fina de manera precoz para establecer el diagnóstico.
Subject(s)
Histiocytosis, Langerhans-Cell/diagnosis , Female , Histiocytosis, Langerhans-Cell/complications , Humans , Infant , Lymphadenitis/etiology , NeckABSTRACT
Most studies focusing on respiratory infections in immunocompromised children have been addressed to bacterial etiology. However, respiratory virus infections in this population can also lead to severe disease. The objective of this study is to evaluate the clinical significance of respiratory virus infections in children with cancer or human immunodeficiency virus (HIV) infection. Retrospective study conducted in a teaching hospital in Madrid. Medical records from children Subject(s)
HIV Infections/complications
, Immunocompromised Host
, Neoplasms/complications
, Respiratory Tract Infections/epidemiology
, Respiratory Tract Infections/immunology
, Respiratory Tract Infections/virology
, Adolescent
, Anti-Bacterial Agents/therapeutic use
, Antiviral Agents/therapeutic use
, Child
, Cross Infection/epidemiology
, Cross Infection/immunology
, Cross Infection/virology
, Female
, Humans
, Male
, Retrospective Studies
, Virus Diseases/drug therapy
, Virus Diseases/epidemiology
, Virus Diseases/immunology
