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J Pediatric Infect Dis Soc ; 10(Supplement_3): S22-S26, 2021 Nov 17.
Article in English | MEDLINE | ID: mdl-34791398

ABSTRACT

Clostridioides difficile infection (CDI) in children is more often acquired in the community than in the hospital. Community-associated Clostridioides difficile infection (CA-CDI) cases seem to be rising, although this is confounded by the unclear role of C. difficile in children 1 and 3 years of age and overreliance on nucleic acid amplification tests for diagnosis. Exposure to antibiotics, acid suppression medications, health care settings, and close contacts with CDI are associated with CA-CDI in children. These infections are more common in children with chronic medical conditions, especially those involving the gastrointestinal tract and immune suppression. Most CA-CDI in children are mild and managed in the outpatient setting, but a small subset requires hospitalization and can be quite severe. Approximately 10% of children with CA-CDI experience a recurrence. Infection control guidance focuses on the hospital setting and future studies on the best methods for preventing community spread of C. difficile are needed.


Subject(s)
Clostridioides difficile , Clostridium Infections , Cross Infection , Child , Clostridioides , Clostridium Infections/diagnosis , Clostridium Infections/drug therapy , Clostridium Infections/epidemiology , Cross Infection/diagnosis , Cross Infection/drug therapy , Cross Infection/epidemiology , Hospitals , Humans
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