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1.
Hyperbaric oxygen as an adjunct in zygomycosis: randomized controlled trial in a murine model.
Barratt, D M; Van Meter, K; Asmar, P; Nolan, T; Trahan, C; Garcia-Covarrubias, L; Metzinger, S E.
Antimicrob Agents Chemother ; 45(12): 3601-2, 2001 Dec.
Article in English | MEDLINE | ID: mdl-11709348

ABSTRACT

Zygomycosis was induced by injecting CD-1 mice with 5 mg of intraperitoneal deferoxamine and then 10(6) CFU of intravenous and intrasinus Rhizopus arrhizus. The addition of hyperbaric oxygen (2.0 atm absolute twice daily) to amphotericin B did not improve survival over that achieved with amphotericin B and placebo air treatments.


Subject(s)
Hyperbaric Oxygenation , Mucormycosis/therapy , Rhizopus , Amphotericin B/therapeutic use , Animals , Antifungal Agents/therapeutic use , Combined Modality Therapy , Deferoxamine/pharmacology , Female , Mice , Mucormycosis/drug therapy , Survival Analysis
2.
Rhino-orbitocerebral mucormycosis attributable to Apophysomyces elegans in an immunocompetent individual: case report and review of the literature.
Garcia-Covarrubias, L; Bartlett, R; Barratt, D M; Wassermann, R J.
J Trauma ; 50(2): 353-7, 2001 Feb.
Article in English | MEDLINE | ID: mdl-11242306

Subject(s)
Brain Diseases/microbiology , Mucormycosis/microbiology , Mucormycosis/therapy , Orbital Diseases/microbiology , Paranasal Sinus Diseases/microbiology , Soft Tissue Infections/microbiology , Accidents, Traffic , Adult , Amphotericin B/therapeutic use , Antifungal Agents/therapeutic use , Brain Diseases/drug therapy , Brain Diseases/surgery , Debridement , Humans , Immunocompetence , Male , Orbit Evisceration , Orbital Diseases/drug therapy , Orbital Diseases/surgery , Paranasal Sinus Diseases/drug therapy , Paranasal Sinus Diseases/surgery
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