ABSTRACT
Presentamos el caso de una paciente que tuvo un parto pretérmino en la semana 34, y estaba diagnosticada de polihidramnios asociado a una imagen ecográfica, inicialmente clasificada como cotiledón placentario accesorio. Tras el análisis histológico se determinó que esa estructura correspondía a un corioangioma gigante, y podría, en nuestra opinión, ser el causante del cuadro clínico que desarrolló la paciente. Dado el reducido número de estudios, y las nuevas posibilidades de tratamiento, consideramos podría ser interesante la exposición del caso
We report the case of a patient with preterm labour at 34 weeks with polyhydramnios associated with an obstetric scan finding initially defined as accessory placental cotyledon. At the histological examination, this was found to be a giant chorioangioma, which in our opinion could be the cause of the patient's clinical symptoms. Due to the lack of studies in the literature and new treatment possibilities, we consider that publication of the case may be of interest
Subject(s)
Humans , Female , Pregnancy , Hemangioma/complications , Polyhydramnios/etiology , Placenta Diseases , Pregnancy Outcome , Prenatal Diagnosis/methods , Ultrasonography, Prenatal , Obstetric Labor, Premature/etiologyABSTRACT
A method based in two-dimensional protein gel electrophoresis has been developed in order to improve the analysis of genetic relationships among populations of Globodera. It has been used to estimate genetic divergence among nine Globodera pallida nematode populations. Sixty-one anonymous polypeptide spots were resolved using silver-stained high-resolution 2D gels and they were quantified in each population to establish genetic variation among G. pallida populations. The results of this analysis were compared with those obtained after a study of allelic frequency variation, which was carried out using seven previously described loci. Genetic distances among populations were calculated by means of both studies, the quantitative analysis and the allelic frequency variation, and phylogenetic trees were constructed for each type of analysis. A correlation analysis between the two distance matrices was carried out and a bootstrap analysis was performed to determine the strength of the clusters obtained with each method. The results obtained support the idea that quantitative protein analysis can be successfully applied to phylogenetic analysis of G. pallida populations.
Subject(s)
Electrophoresis, Gel, Two-Dimensional/methods , Nematoda/genetics , Protozoan Proteins/analysis , Animals , Cluster Analysis , Gene Frequency , Genetic Variation , Genetics, Population , Isoelectric Point , Phylogeny , Selection, GeneticABSTRACT
To determine whether criteria for not admitting community-acquired pneumonia (CAP) patients diagnosed in the emergency room are appropriate, and to characterize the symptoms, etiology and course of CAP. This one-year prospective, protocol study of immunocompetent CAP patients diagnosed in the emergency room of our hospital enrolled patients not considered to require hospital admission according to the recommendations of the Spanish Society of Respiratory Disease (SEPAR). Medical histories, chest X-rays and blood analysis were obtained for all patients. Blood cultures were analyzed for antibodies against Legionella pneumophila, Mycoplasma pneumoniae, Coxiella burnetii, Chlamydia pneumoniae, Chlamydia psittaci and influenza virus types A and B. The patients received erythromycin for 14 days and were regularly checked by the pulmonologist in the outpatient clinic until signs and symptoms had disappeared. One hundred six patients were enrolled. Mean age was 36 +/- 13 years. Only 3 patients had to be admitted to hospital, after which outcome was good. The main symptoms were fever (106, 100%) and cough (83, 78%). In 46 (43.4%) chest sounds were normal. Microbiologic diagnoses were achieved for 28 (26.4%) and Coxiella burnetii was the agent most often found (19, 17.9%). Outcome was good in all cases, with faster disappearance of symptoms than of radiological signs. The SEPAR criteria for admitting patients with CAP are appropriate. The clinical symptoms of such patients are non specific, a noteworthy finding being that many patients had normal chest sounds. Coxiella burnetii was the most common causative agent. Both clinical and radiological outcomes were excellent.
