ABSTRACT
Even when there is not direct relation between psoriasis and AIDS, there have been reported impressive manifestations of psoriasis in AIDS diagnosis, difficulties in response to therapy, increase of serious forms of the disease, and clearing of lesions in terminal phase of AIDS. Two cases in which the two diseases are associated were presented. Both cases had outbreaking psoriasis guttata, one of them after being diagnosed with AIDS, in addition to have other dermatosis such as leukoplasia and ungual candidiasis; and the two patients also had scabies. Additionally, presentation of generalized lesions resistant to prescribed therapies was observed.
Subject(s)
Acquired Immunodeficiency Syndrome/diagnosis , HIV-1 , Psoriasis/diagnosis , Acquired Immunodeficiency Syndrome/complications , Adult , Humans , Male , Psoriasis/etiologyABSTRACT
The origin and evolution of the classical swine fever (CSF) epizootic that occurred in Cuba from 1993 to 1997 has been investigated by the analysis of E2 gene sequences from 15 representative viral isolates as well as the vaccine and the challenge strains used in this country. In the phylogenetic tree derived from these sequences, the Cuban isolates were located in a defined cluster within the previously reported genomic subgroup 1.2. This cluster was related, although distinguishable, from the live vaccine used in Cuba since 1965. Two further groups were identified. One of them included the early viruses isolated in the western part of Cuba until 1996 and the strain Margarita, used for vaccine potency tests since 1965. These results are consistent with the strain Margarita being the origin of the western outbreaks. The viruses isolated from 1996 in eastern Cuba defined a related, but independent group. The level of sequence variation observed in this group does not exclude an independent origin for the eastern isolates.
Subject(s)
Classical Swine Fever Virus/genetics , Classical Swine Fever/epidemiology , Viral Envelope Proteins/genetics , Amino Acid Sequence , Animals , Base Sequence , Classical Swine Fever/physiopathology , Classical Swine Fever/virology , Classical Swine Fever Virus/classification , Classical Swine Fever Virus/isolation & purification , Cuba/epidemiology , DNA, Viral/chemistry , DNA, Viral/genetics , Molecular Epidemiology , Molecular Sequence Data , Phylogeny , Swine , Viral Envelope Proteins/chemistryABSTRACT
A simple reverse transcriptase-polymerase chain reaction (RT-PCR) assay has been developed for the specific amplification of DNA after reverse transcription of RNA from the classical swine fever virus (CSFV). A pair of oligonucleotides was selected from an area of high homology in the genome of CSFV strains, but which differed from the corresponding sequences in the genome of bovine viral diarrhea virus (BVDV) strains. Using these primers (CSFV1-CSFV2), a CSFV specific DNA band of 174 bp was amplified from the CSFV RNA extracted from four reference strains and 14 field isolates, as well as from 25 organ extracts and eight buffy coats and serum samples of experimentally infected animals. No amplification was observed with the RNA from four BVDV reference and vaccine strains and seven field isolates. This RT-PCR assay made it possible, in a one-step reaction, to detect CSFV rapidly, sensitively and specifically in cell culture supernatants and in clinical specimens.
Subject(s)
Classical Swine Fever Virus/isolation & purification , Classical Swine Fever/diagnosis , Reverse Transcriptase Polymerase Chain Reaction/methods , Animals , Bovine Virus Diarrhea-Mucosal Disease/diagnosis , Cattle , Classical Swine Fever Virus/genetics , Fluorescent Antibody Technique, Direct , Lymph Nodes/virology , Palatine Tonsil/virology , Pestivirus/genetics , RNA, Viral/genetics , RNA, Viral/isolation & purification , Reproducibility of Results , Reverse Transcriptase Polymerase Chain Reaction/veterinary , Sensitivity and Specificity , Spleen/virology , SwineSubject(s)
Movement Disorders/diagnosis , Movement Disorders/etiology , Embryonic and Fetal Development , Female , Gestational Age , Humans , Infant , Male , Phenotype , Prognosis , SyndromeABSTRACT
It is reported this uncommon variety of scabies in Cuban patients that caused an epidemic in its areas of origin. It is stressed the severe prutitus observed among these patients, which is usually mild or is absent. It is recommended the dermatological isolation of these individuals and the adoption of prophylactic measures for the personnel being in direct contact with them.
Subject(s)
Disease Outbreaks , Scabies/epidemiology , Acquired Immunodeficiency Syndrome/complications , Adult , Aged , Aged, 80 and over , Cuba/epidemiology , Female , Humans , Immunocompromised Host , Institutionalization , Male , Scabies/prevention & control , Scabies/transmissionABSTRACT
A case of Stevens-Johnson syndrome and infection caused by the human immunodeficiency virus (HIV) diagnosed at the "Pedro Kourí" Institute of Tropical Medicine was reported. This retrospective study was conducted through a bibliographic review. It is a HIV seropositive female patient that during her disease presented dermatological alterations, such as vesicles and ampullas that corresponded to the Stevens-Johnson syndrome. The nursing role in the treatment of an immunodepressed patient and the correct application of the biosafety measures are explained in detail. The nursing personnel is considered as an inseparable part of the medical team in the attention to the HIV immunodepressed patient from the Stevens-Johnson syndrome.
Subject(s)
HIV Seropositivity/complications , Immunocompromised Host , Infection Control/methods , Stevens-Johnson Syndrome/complications , Stevens-Johnson Syndrome/nursing , Adult , Female , Humans , Retrospective StudiesABSTRACT
OBJECTIVE: Since its casual discovery and implication as a human pathogen that provokes transitory aplastic crises and infectious erythema, the B19 parvovirus has been related to a wide spectrum of diseases. To better understand this clinical diversity, we reviewed the cases of a serology positive infants admitted to the hospital. PATIENTS AND METHODS: From January 1992 to June 1995, all clinical charts were reviewed and we obtained 15 patients that had positive IgM antibodies by immunoenzyme assay. RESULTS: The mean age was 12.2 months. No sex differences were seen. The incidence was higher in winter months. Over 50% of the patients belong to the last year studied. Clinical findings included 5 cases of arthritis (one juvenile rheumatoid arthritis, one polyarticular syndrome and 3 nonspecific forms), hematology disturbances in 5 cases (1 case of erythrophagocytosis, 1 of thrombocytopenic purpura, 2 of anemia and 1 chronic neutropenia), 3 cases of febrile syndrome, 1 liver dysfunction, and 1 neuromyelitis. Complementary exams were not significant and follow-up in all infants was satisfactory. CONCLUSIONS: The B19 parvovirus, a poorly understood virus, is related to many clinical situations where is true significance remains unknown.
Subject(s)
Parvoviridae Infections/diagnosis , Parvoviridae Infections/virology , Parvovirus B19, Human/isolation & purification , Age Distribution , Female , Humans , Immunoglobulin M/immunology , Infant , Male , Parvoviridae Infections/immunology , Retrospective StudiesABSTRACT
The clinical histories of 12 AIDS patients whose histoplasmosis diagnosis has been confirmed by histopathological studies were reviewed aimed at knowing the main clinical and microbiological aspects of the disseminated progressive histoplasmosis. In every case it appeared as a febrile and waste disease with an elevated hepatomegaly frequency and generalized adenopathies. More than 50% of the patients had anemia and an accelerated erythrocyte sedimentation. The chest X-ray showed pulmonary lesions in 50% of the patients, whereas, the abdominal ultrasound allowed to observe hepatomegaly and splenomegaly in 58.3 and 41.6% of the patients, respectively. A low sensitivity was found in the culture of different clinical specimens as well as in the antibody detection techniques. It is discussed the need to improve tha laboratory diagnosis methods, particularly those which make possible the antigen detection in a fast and specific way.
Subject(s)
AIDS-Related Opportunistic Infections/diagnosis , HIV-1 , Histoplasmosis/diagnosis , AIDS-Related Opportunistic Infections/microbiology , Adolescent , Adult , Antibodies, Fungal/blood , CD4 Lymphocyte Count , Disease Progression , Female , Histoplasma/immunology , Histoplasma/isolation & purification , Histoplasmosis/microbiology , Humans , Male , Retrospective StudiesABSTRACT
Se presenta el caso de una paciente que fue estudiada durante cinco años por presentar niveles de anticuerpo anti-glicilípido fenólico I, específico de M. leprae, superiores al valor de corte estabelecido, los cuales disminuyeron hasta la negativación sin tratamiento específico. No se constaron signos clínicos de lepra durante la etapa de vigilancia dermatológica, estimándose que este comportamiento pudiera corresponderse con el curso de la infección subclinicca de lepra.
Subject(s)
Leprosy/classification , Leprosy/epidemiologyABSTRACT
The case of a five-year-old mulatto girl with craniofacial dysmorphism, infected with AIDS virus, is presented. The girl had ocular hypertelorism; eyes slanted upwards; increase of the distance between the internal and external canthi; prominent triangular philtrum; thick lips; prominent forehead; flat nasal bridge; large parotid glands, which indicate that the infection must have transmitted during fetal life. These features were not observed in children infected with AIDS through other ways such as perinatal transmission, blood transfusions and breastfeeding.
Subject(s)
Abnormalities, Multiple , Acquired Immunodeficiency Syndrome/complications , Facial Bones/abnormalities , Skull/abnormalities , Child, Preschool , Female , HumansABSTRACT
The most important clinical and epidemiological aspects of the lymphogranuloma venereum as a sexually-transmitted disease are described. We present a summary of the clinical history of an HIV-positive patient who presented with a tumoral lesion in the inguinal region presumptive of lymphogranuloma venereum. The diagnostic value of the polymerase chain reaction (PCR) technique for the establishment of an accurate diagnosis is stressed the epidemiological importance of the report of this sexually-transmitted disease in an HIV-positive patient for the first time in Cuba is also pointed out. A good response was attained with Doxycycline.
Subject(s)
HIV Seropositivity/complications , Lymphogranuloma Venereum/complications , Adult , Cuba/epidemiology , Humans , Lymphogranuloma Venereum/epidemiology , MaleABSTRACT
The case of a Cuban child with AIDS acquired by perinatal transmission is reported. Thirteen days after birth, the child had chronic diarrhoeas affecting its pondostatural development. It was hospitalized many times due to recurrent respiratory processes, in one of which Pneumocystis carinii was detected. Oral candidiasis, cryptosporidiosis and intestinal amebiasis in faeces were also diagnosed. It died with generalized tonic-clonic convulsions and bradypnea. At autopsy, the direct death cause was endocranial hypertension due to unspecific sub-acute viral meningitis.
Subject(s)
Acquired Immunodeficiency Syndrome/pathology , HIV-1 , AIDS-Related Opportunistic Infections/pathology , Acquired Immunodeficiency Syndrome/complications , Acquired Immunodeficiency Syndrome/congenital , Child, Preschool , Cryptosporidiosis/pathology , Cuba , Entamoebiasis/pathology , Fatal Outcome , Female , Humans , Pneumonia, Pneumocystis/pathologySubject(s)
Fascioliasis/complications , Urticaria/etiology , Adult , Fasciola hepatica , Fascioliasis/diagnosis , Female , Humans , Male , Middle Aged , Retrospective StudiesABSTRACT
En este trabajo se aborda el problema de como evaluar la calidad de un registro.Luego de esbozar un conjunto de delimitaciones acerca de los aspectos que deben investigarse y de los procedimientos a seguir con tal finalidad, se expone la experiencia de los autores en la evaluacion realizada sobre la informacion contenida en el Registro Nacional de Profisionales de la Salud. Por ese conducto se ilustran algunas tecnicas de analisis del problema
Subject(s)
Health , Information Systems , StatisticsABSTRACT
En este trabajo se aborda el problema de como evaluar la calidad de un registro.Luego de esbozar un conjunto de delimitaciones acerca de los aspectos que deben investigarse y de los procedimientos a seguir con tal finalidad, se expone la experiencia de los autores en la evaluacion realizada sobre la informacion contenida en el Registro Nacional de Profisionales de la Salud. Por ese conducto se ilustran algunas tecnicas de analisis del problema
