ABSTRACT
Within the last few decades, the need for subject authentication has grown steadily, and biometric recognition technology has been established as a reliable alternative to passwords and tokens, offering automatic decisions. However, as unsupervised processes, biometric systems are vulnerable to presentation attacks targeting the capture devices, where presentation attack instruments (PAI) instead of bona fide characteristics are presented. Due to the capture devices being exposed to the public, any person could potentially execute such attacks. In this work, a fingerprint capture device based on thin film transistor (TFT) technology has been modified to additionally acquire the impedances of the presented fingers. Since the conductance of human skin differs from artificial PAIs, those impedance values were used to train a presentation attack detection (PAD) algorithm. Based on a dataset comprising 42 different PAI species, the results showed remarkable performance in detecting most attack presentations with an APCER = 2.89% in a user-friendly scenario specified by a BPCER = 0.2%. However, additional experiments utilising unknown attacks revealed a weakness towards particular PAI species.
Subject(s)
Biometric Identification , Algorithms , Biometry , Electric Impedance , Fingers , HumansABSTRACT
Telephone helplines is an effective method for helping patients with chronic diseases, including inflammatory bowel disease (IBD). The objective of this cross-sectional multicenter study was to assess reasons for consultation by patients with IBD to a nurse-led telephone service. The sample included 7,273 IBD patients from 6 public hospitals in Barcelona, Spain. Data collected included calls registered during 50 working days including caller characteristics, reason for consultation, patient's diagnosis, and action recommended. The most common reasons for consultation were suspicion of relapse, doubts regarding medication, drug monitoring, side effects, visit appointment, and request of test results. In 63.7% of cases, telephone calls were solved solely by nurses, and in 35.9% in collaboration with a physician. Patient's questions were resolved via telephone in 89.3%. Findings from this study add support of the nurse's role for providing an effective telephone service for resolution of a wide range of patient queries in IBD. Helplines managed by IBD nurses may be a key element for patient-centered care.
Subject(s)
Hotlines/organization & administration , Inflammatory Bowel Diseases/nursing , Nurse's Role , Practice Patterns, Nurses' , Cross-Sectional Studies , Female , Hospitals, Urban , Humans , Male , Patient-Centered Care/organization & administration , Program Development , Program Evaluation , SpainABSTRACT
Efficient human immunodeficiency virus (HIV)-1 infection depends on multiple interactions between the viral gp41/gp120 envelope (Env) proteins and cell surface receptors. However, cytoskeleton-associated proteins that modify membrane dynamics may also regulate the formation of the HIV-mediated fusion pore and hence viral infection. Because the effects of HDAC6-tubulin deacetylase on cortical alpha-tubulin regulate cell migration and immune synapse organization, we explored the possible role of HDAC6 in HIV-1-envelope-mediated cell fusion and infection. The binding of the gp120 protein to CD4+-permissive cells increased the level of acetylated alpha-tubulin in a CD4-dependent manner. Furthermore, overexpression of active HDAC6 inhibited the acetylation of alpha-tubulin, and remarkably, prevented HIV-1 envelope-dependent cell fusion and infection without affecting the expression and codistribution of HIV-1 receptors. In contrast, knockdown of HDAC6 expression or inhibition of its tubulin deacetylase activity strongly enhanced HIV-1 infection and syncytia formation. These results demonstrate that HDAC6 plays a significant role in regulating HIV-1 infection and Env-mediated syncytia formation.
Subject(s)
CD4-Positive T-Lymphocytes/virology , HIV Envelope Protein gp120/physiology , HIV Infections/metabolism , HIV-1 , Histone Deacetylases/physiology , Acetylation/drug effects , Aminobenzoates/pharmacology , CD4-Positive T-Lymphocytes/metabolism , Cell Fusion , Cell Line, Tumor , Gene Silencing/physiology , HIV Infections/blood , HeLa Cells , Histone Deacetylase 6 , Histone Deacetylases/genetics , Humans , Hydroxamic Acids/pharmacology , Jurkat Cells , Pyrazines/pharmacology , RNA, Small Nuclear , Transfection , Tubulin/metabolismABSTRACT
Se investigaron 81 niños del círculo infantil Constructores del futuro, del Municipio Playa, provincia Ciudad de la Habana, durante los años 1980-1981. Los niños cuyas heces fueron positivas de Giardia lamblia resultaron 17 para el 21(por ciento) de parasitados por este protozoo. Los mayores porcentajes de positividad se registraron en los grupos de 3-4 años el 50(por ciento)de los niños de 4 años estaban infestados. No sé encontró correspondencia con el sexo, ni relación de la infestación con el personal. No sé encontró correspondecia con el sexo, ni relación de la infestación con el personal asistencial del círculo. No hubo diferencia significativa entre las drogas utilizadas: metronidazol o quinacrina. Todos los niños tratados aumentaron su hemoglobina y disminuyeron su eosinofilia(AU)
