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Expression of Stem Cell Markers in Preinvasive Tubal Lesions of Ovarian Carcinoma.
Chene, G; Ouellet, V; Rahimi, K; Barres, V; Meunier, L; De Ladurantaye, M; Provencher, D; Mes-Masson, A M.
Biomed Res Int ; 2015: 808531, 2015.
Article in English | MEDLINE | ID: mdl-26504831

ABSTRACT

In order to better understand the ovarian serous carcinogenic process with tubal origin, we investigated the expression of stem cell markers in premalignant tubal lesions (serous tubal intraepithelial carcinoma or STIC). We found an increased stem cell marker density in the normal fallopian tube followed by a high CD117 and a low ALDH and CD44 expression in STICs raising the question of the role of the stem cell markers in the serous carcinogenic process.


Subject(s)
Biomarkers, Tumor/analysis , Fallopian Tube Neoplasms/chemistry , Ovarian Neoplasms/chemistry , Biomarkers, Tumor/metabolism , Fallopian Tube Neoplasms/metabolism , Fallopian Tubes/chemistry , Fallopian Tubes/metabolism , Female , Humans , Hyaluronan Receptors/analysis , Hyaluronan Receptors/metabolism , Ovarian Neoplasms/metabolism , Proto-Oncogene Proteins c-kit/analysis , Proto-Oncogene Proteins c-kit/metabolism , Tissue Array Analysis
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