Cell proliferation markers in the odontogenic keratocyst: effect of inflammation / Proliferação de células marcadoras em queratocistos odontogênicos: efeito da inflamação

The immunohistochemical expression of PCNA and Ki-67 proteins and the histochemical expression of AgNORs were studied in 20 odontogenic keratocysts in order to assess the relationship between epithelial cell proliferation and inflammation within the capsule. Immunostained cells were quantified by conventional methods, and both quantitative and morphometric analyses of AgNORs were performed by TV image analysis. Non-inflamed odontogenic keratocysts showed a typical epithelial lining and inflamed odontogenic keratocysts were lined also by hyperplastic non-keratinized stratified squamous epithelium. A statistically significant increase of PCNA+ and ki-67+ cells and of AgNOR numbers was detected in the linings of inflamed odontogenic keratocysts compared to non-inflamed lesions. The results suggest the existence of greater proliferative activity in the epithelial cells of inflamed odontogenic keratocysts, which may be associated with the disruption of the typical structure of odontogenic keratocyst linings

Diagnóstico das lesões fibro-ósseas benignas da maxila e mandíbula / Diagnosis of benign fibro-osseous jaw lesions

As lesões fibro-ósseas benignas constituem um importante grupo de alterações patológicas da maxila e mandíbula. A diversidade de termos utilizados para denominar estas entidades dificulta o entendimento entre clínicos, radiologistas e patologistas. O propósito dos autores neste estudo é fazer uma revisão conceitual destas lesões, ressaltando os principais aspectos clínicos, radiográficos e histológicos da sua ocorrência no complexo maxilo-mandibular