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Association of t(9;11)-MLL AF9 and trisomy 8 in an AML-M5 preceded by pancytopenia.
Anguita, E; Barrio, C G; González, F A; Ferro, M T; del Potro, E; Ropero, P; Villegas, A.
Cancer Genet Cytogenet ; 120(2): 144-7, 2000 Jul 15.
Article in English | MEDLINE | ID: mdl-10942806

ABSTRACT

The implication of MLL gene rearrangements in the prognosis of acute myeloblastic leukemia is an issue of considerable current interest. We report a case of a young man who initially presented with a pancytopenia and went on to develop a highly-aggressive acute myeloblastic leukemia. At this time, the karyotypic study revealed trisomy 8, a t(9;11) was demonstrated by fluorescence in situ hybridization (FISH) and the MLL/AF4 rearrangement by reverse transcriptase-polymerase chain reaction (RT-PCR).


Subject(s)
Chromosomes, Human, Pair 11/genetics , Chromosomes, Human, Pair 8/genetics , Chromosomes, Human, Pair 9/genetics , Leukemia, Monocytic, Acute/genetics , Pancytopenia/pathology , Proto-Oncogenes , Transcription Factors , Trisomy , Adult , Blotting, Southern , Cytogenetic Analysis , DNA, Neoplasm/genetics , DNA-Binding Proteins/genetics , Histone-Lysine N-Methyltransferase , Humans , In Situ Hybridization, Fluorescence , Karyotyping , Leukemia, Monocytic, Acute/pathology , Male , Myeloid-Lymphoid Leukemia Protein , Nuclear Proteins/genetics , Oncogene Proteins, Fusion/genetics , Pancytopenia/genetics , Translocation, Genetic
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