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Phytomedicine ; 16(10): 982-8, 2009 Oct.
Article in English | MEDLINE | ID: mdl-19303754

ABSTRACT

Curcumin is a phenolic natural product isolated from the rhizome of Curcuma longa (tumeric). It was previously described that curcumin had a potent anti-inflammatory effect and inhibited the proliferation of a variety of tumor cells. In the present study, we investigated the inhibitory effects of curcumin on the response of normal murine splenic B cells. Curcumin inhibited the proliferative response of purified splenic B cells from BALB/c mice stimulated with the Toll-like receptor ligands LPS and CpG oligodeoxynucleotides. LPS-induced IgM secretion was also inhibited by curcumin. The proliferative response induced by either the T-independent type 2 stimuli anti-delta-dextran or anti-IgM antibodies was relatively resistant to the effect of curcumin. We investigated the intracellular signaling events involved in the inhibitory effects of curcumin on murine B cells. Curcumin did not inhibit the increase in calcium levels induced by anti-IgM antibody. Western blotting analysis showed that curcumin inhibited TLR ligands and anti-IgM-induced phosphorylation of ERK, IkappaB and p38. Curcumin also decreased the nuclear levels of NFkappaB. Our results suggested that curcumin is an important inhibitor of signaling pathways activated upon B cell stimulation by TLR ligands. These data indicate that curcumin could be a potent pharmacological inhibitor of B cell activation.


Subject(s)
Anti-Inflammatory Agents, Non-Steroidal/pharmacology , B-Lymphocytes/drug effects , Curcumin/pharmacology , Signal Transduction/drug effects , Toll-Like Receptors/metabolism , Animals , Antibodies, Anti-Idiotypic , B-Lymphocytes/metabolism , Calcium/metabolism , Cell Proliferation/drug effects , Cells, Cultured , Curcuma , Female , Ligands , Male , Mice , Mice, Inbred BALB C
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