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Holist Nurs Pract ; 26(1): 52-7, 2012.
Article in English | MEDLINE | ID: mdl-22157509

ABSTRACT

This was a prospective, randomized, between-subjects experimental study to investigate the anxiolytic effects of naringenin, a component of mentha aquatica, and its potential interaction with the benzodiazepine binding site on the γ-aminobutyric acid (GABAA) receptor in the rat. Fifty-five rats were assigned to one of 5 groups with 11 rats per group: control, naringenin, midazolam, midazolam with naringenin, and flumazenil with naringenin. The elevated plus maze measured the behavioral components of anxiety and motor movements. Our data suggest that naringenin does not produce anxiolysis by modulation of the GABAA receptor; however, the findings indicate that naringenin decreases motor movements (P < .05).


Subject(s)
Anti-Anxiety Agents/therapeutic use , Anxiety/drug therapy , Flavanones/therapeutic use , Mentha/chemistry , Motor Activity/drug effects , Phytotherapy , Plant Extracts/therapeutic use , Animals , Anti-Anxiety Agents/pharmacology , Behavior, Animal/drug effects , Benzodiazepines/metabolism , Binding Sites , Flavanones/pharmacology , Herb-Drug Interactions , Male , Maze Learning/drug effects , Plant Extracts/pharmacology , Prospective Studies , Random Allocation , Rats , Rats, Sprague-Dawley , Receptors, GABA-A/metabolism , gamma-Aminobutyric Acid/metabolism
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