The influence of diabetes mellitus on survival of abdominal perforator flaps: an experimental study in rats with slowly induced diabetes mellitus.

BACKGROUND: Lower limb ulcers are a major source of morbidity and mortality in diabetic patients. Surgical coverage of these wounds is fraught with a high complication rate. Although clinically perforator flaps lead to good results in diabetic patients, there is little experimental data to support this finding. METHODS: A total of 60 Wistar rats were randomly assigned either to the diabetic (n = 30) or control (n = 30) group. Diabetes was induced by streptozotocin injection at 50 mg/kg body weight and was confirmed by blood glucose levels > 180 mg/dL preoperatively. In all rats, a cranial epigastric artery perforator flap was raised. At postoperative day 7, all flaps were raised, photographed by digital planimetry, and analyzed histologically. RESULTS: Mean glycemic levels preoperatively were 207.8 ± 16 in the diabetic group and 82.8 ± 5.1 in the control group (p < 0.05). Ninety percent of the flaps survived completely in the control group, compared with 66.7% in the diabetic group (p < 0.05). The mean flap survival area was lower in the diabetic group (83.3 ± 16.5%) than in the control group (96 ± 4%). There were significantly more perioperative complications in the diabetic group (46.7%) than in the control group (16.7%), but these did not affect flap survival. Superficial ulceration appeared only in the diabetic group as a complication. CONCLUSION: Perforator flaps can be successfully used for coverage of cutaneous defects in a rat diabetic model. These flaps show higher complication rates in diabetic versus nondiabetic animals; however, this complication rate has little influence on flap survival.

[Eye lid reconstruction after bilateral palpebral complete necrosis after an extensive Pseudomonas aeruginosa infection (infected neonatal hordeolum)]. / Reconstructie palpebrala dupa necroza bilaterala completa de pleoape, cu postinfectie locala extensiva cu Pseudomonas aeruginosa (orjelet neona- tal suprainfectat).

In this article we will present a clinical case particularly interesting in terms of diagnosis, treatment and evolution of a infant who presented in our service because very serious evolution of a hordeolum, with infection and then complete necrosis of lower and upper eyelids of both eyes. The substrate counterproductive evolution was identified later, by genetic analysis (X-linked Bruton congenital agammaglobulinemia).