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Biochem Biophys Res Commun ; 189(1): 85-91, 1992 Nov 30.
Article in English | MEDLINE | ID: mdl-1449509

ABSTRACT

In Saccharomyces cerevisiae treated with an antifungal agent, 6-amino-2-n-pentylthiobenzothiazole, levels of ergosterol and other 4-desmethylsterols were found to be significantly reduced. Major sterols in treated yeast were lanosterol, 4,4-dimethylzymosterol, 4-methylzymosterol and 4-methylfecosterol. A hypothesis is stated that the antifungal agent inhibits sterol demethylation at C-4 and forces the biosynthesis to a blind pathway ending by 4-methylfecosterol.


Subject(s)
Antifungal Agents/pharmacology , Ergosterol/metabolism , Saccharomyces cerevisiae/drug effects , Sterols/metabolism , Thiazoles/pharmacology , Gas Chromatography-Mass Spectrometry , Kinetics , Saccharomyces cerevisiae/growth & development , Saccharomyces cerevisiae/metabolism , Sterols/biosynthesis , Sterols/isolation & purification
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