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1.
[Changes in the pharmaceutical and biological availability of aminophylline from suppositories containing non-ionogenic surface-active agents after a year of storage]. / Zmiany dostepnosci farmaceutycznej i biologicznej aminofiliny z czopków w obecnosci niejonogennych tenzydów w czasie rocznego przechowywania.
Bartkowicz, S; Pawlik, T; Krówczynski, L; Gudowska, T; Gacek, M.
Acta Pol Pharm ; 42(2): 165-71, 1985.
Article in Polish | MEDLINE | ID: mdl-4083053

Subject(s)
Aminophylline/metabolism , Surface-Active Agents/pharmacology , Animals , Biological Availability , Drug Stability , Drug Storage , Male , Rabbits , Rectum , Suppositories , Time Factors
2.
In vitro study of (2S, 2'S) N,N'-dimethyl-N, N'-bis [1(3', 4', 5'-trimethoxybenzoyloxy) butyl-2] ethylenediamine salts and their bioavailability.
Krówczynski, L; Kluczykowska, B; Stozek, T; Wajdowicz, A; Bartkowicz, S.
Pol J Pharmacol Pharm ; 32(6): 909-15, 1980.
Article in English | MEDLINE | ID: mdl-7243687

ABSTRACT

The aim of this study was to improve the oral dosage form of the title compound. The study include base, dihydrochloride and dimaleate. In vitro study was carried out on rat intestine, in vivo on rats and rabbits. The low absorption of the M-71 salts has been shown in both in vitro and in vivo studies. To increase bioavailability in men the tablets or enteric coated tablets should be made according to the results of clinical trials.


Subject(s)
Anti-Arrhythmia Agents/metabolism , Ethylenediamines/metabolism , Administration, Oral , Animals , Anti-Arrhythmia Agents/administration & dosage , Biological Availability , In Vitro Techniques , Intestinal Mucosa/metabolism , Male , Rabbits , Rats , Tablets , Tablets, Enteric-Coated
3.
[Pharmaceutical and biological availability of aminophylline in suppositories containing non-ionic surface-active agents]. / Dostepnosc farmaceutyczna i biologiczna z czopków w obecnosci niejonogennych tenzydów typu Span.
Bartkowicz, S; Pawlik, T; Rosiek-Pawlowska, A.
Folia Med Cracov ; 21(1): 179-91, 1979.
Article in Polish | MEDLINE | ID: mdl-540870

Subject(s)
Aminophylline/metabolism , Animals , Diffusion , Drug Storage , Glycerol/pharmacology , Half-Life , In Vitro Techniques , Kinetics , Rabbits , Solubility , Sorbitol/pharmacology , Suppositories
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