ABSTRACT
The authors compared the activity of daptomycin with that of ampicillin, penicillin, teicoplanin and vancomycin against 304 strains of Enterococcus species isolated from blood and urine. Daptomycin was as active as penicillin against Enterococcus faecalis: 90% of strains were inhibited by 2 mg/L. Daptomycin was more active than vancomycin (90% minimal inhibitory concentration [MIC(90)] 2 mg/L; 90% minimal bactericidal concentration [MBC(90)] 8 mg/L) but was less active than teicoplanin (MIC(50) 0.25; MBC(90) 8 mg/L) or ampicillin (MIC(90) 1 mg/L; MBC(90) 2 mg/L) against E faecalis. In time-kill studies daptomycin was not more rapidly bactericidal than ampicillin or penicillin but was significantly more rapidly bactericidal than either teicoplanin or vancomycin. In combination with gentamicin, daptomycin has activity similar to that of penicillin, vancomycin and teicoplanin. Daptomycin may be a suitable alternative to penicillin in patients allergic to penicillins or for the treatment of enterococcal infections caused by beta-lactamase-producing enterococci.
ABSTRACT
The proportion of enterococci isolated from blood and urine cultures that were highly resistant to gentamicin and streptomycin were determined. No blood or urine isolates highly resistant to gentamicin were seen in 1983, whereas by 1986-87 25% of blood and 17% of urine isolates were highly resistant. The rapid emergence of gentamicin resistance has serious implications for patients with life threatening enterococcal disease.
ABSTRACT
We compared the in vitro activity of lomefloxacin with that of other agents against 336 strains of Haemophilus influenzae and Branhamella catarrhalis isolated from the respiratory tract of a predominantly adult and in-patient population. H. influenzae strains were usually not serotypable. No strains were resistant to lomefloxacin; all strains tested were susceptible to 0.25 micrograms/ml. The lomefloxacin MIC50 and MIC90 was 0.125 micrograms/ml.
