ABSTRACT
The paper describes a case of twin pregnancy with complete hydatidiform mole (CHM). According to the data available in the literature, the concurrence of CHM with a normal placenta and a viable fetus occurs in 1 per 20,000-100,000 pregnancies, requires a differential diagnosis with partial hydatidiform mole and placental mesenchymal dysplasia, and is characterized by a high rate of complications. In this concurrence, the frequency of persistent trophoblastic disease is as high as 50%. In this case, the pregnancy ended in a spontaneous abortion at 16-17 weeks of pregnancy. A morphological examination determined the fetus without congenital malformations with normal placental weight and structure and the adjacent intact placental tissue with the macro- and microscopic signs of CHM. The diagnosis was confirmed by the lack of Ñ57 expression in the villous trophoblast and stroma in the tissue of the hydatidiform mole. The patient was diagnosed with persistent trophoblastic disease at 2 months after the abortion.
Subject(s)
Gestational Trophoblastic Disease/physiopathology , Hydatidiform Mole/physiopathology , Pregnancy Complications, Neoplastic/physiopathology , Pregnancy, Twin , Abortion, Spontaneous/physiopathology , Adult , Female , Fetus/physiopathology , Gestational Trophoblastic Disease/complications , Humans , Hydatidiform Mole/complications , Placenta/physiopathology , PregnancySubject(s)
Carcinoma, Squamous Cell/pathology , Neoplasms, Multiple Primary , Stomach Neoplasms/pathology , Uterine Cervical Neoplasms/pathology , Aged , Biopsy, Needle , Carcinoma, Squamous Cell/surgery , Diagnosis, Differential , Female , Follow-Up Studies , Gastrectomy/methods , Gastroscopy , Humans , Hysterectomy/methods , Laparotomy , Stomach Neoplasms/surgery , Uterine Cervical Neoplasms/surgeryABSTRACT
The effects of a variety of doses of systemically administered cysteamine (a somatostatin depletor) were studied on step-through passive avoidance retention, as well as acquisition and performance of a delayed spatial alternation task and a signaled extinction discrimination task in rats. Retention of single trial passive avoidance was significantly reduced by a pretraining (60-min) dose of cysteamine at 50, 100, 150 and 200 mg/kg s.c. This effect was shown to be sensitive to behavioral manipulation; in a second experiment, a retention deficit was found only at the two highest doses tested (150 and 200 mg/kg s.c.) after a second exposure to the footshock. In the operant conditioning studies, biweekly injections (Monday and Wednesday) of cysteamine administered one hour before testing produced no statistically significant changes in acquisition or performance of either the delayed spatial alternation or the signaled discrimination task. The results of these series of experiments suggest that active somatostatin release or chronic somatostatin depletion may selectively affect performance maintained by different behavioral procedures.
