ABSTRACT
Hibernoma is a rare benign tumour of brown fat. In most cases it presents as a voluminous slow-growing mass in the regions where remnants of brown fat can remain in adults. We report a case of a hibernoma on the thigh and present the diagnostic and therapeutic elements of this type of tumour, whose differential diagnosis of liposarcoma.
Subject(s)
Lipoma/diagnosis , Soft Tissue Neoplasms/diagnosis , Adult , Diagnosis, Differential , Female , Humans , Lipoma/surgery , Liposarcoma/diagnosis , Magnetic Resonance Imaging , Soft Tissue Neoplasms/surgery , Thigh , Tomography, X-Ray ComputedABSTRACT
A series of iron porphyrins bearing one to eight beta-nitro substituents were synthesized and evalauted as catalysts for hydrocarbon oxidation with H2O2; iron porphyrins bearing five or six beta-nitro groups were the best catalysts for cyclooctene epoxidation and adamantane or anisole hydroxylation without need of a cocatalyst, and led to very different regioselectivities with either H2O2 or PhIO as oxidants, as shown by an unusual ortho-hydroxylation of alkoxybenzenes highly favored in the H2O2-dependent oxidations.
Subject(s)
Sella Turcica/diagnostic imaging , Aneurysm/diagnostic imaging , Carotid Artery, Internal/diagnostic imaging , Cavernous Sinus/diagnostic imaging , Craniopharyngioma/diagnostic imaging , Humans , Meningeal Neoplasms/diagnostic imaging , Meningioma/diagnostic imaging , Optic Chiasm/diagnostic imaging , Pituitary Gland/blood supply , Pituitary Neoplasms/diagnostic imaging , Radiography , Sphenoid Sinus/diagnostic imagingABSTRACT
Primary and secondary aliphatic nitroalkanes RR'CHNO2, react with microsomal cytochrome p-450 in the presence of dithionite leading to new complexes with a Soret peak at 455 nm. The formation of these complexes is inhibited completely by CO and partially by metyrapone. However, once formed, their exogenous ligand is not displaced by excess CO. By deoxycholate treatment they are transformed into 423-nm-absorbing cytochrome P-420 complexes, which are spectrally similar to the corresponding RR'CHNO2-derived myoglobin complexes. The 455-nm-absorbing complexes are equally produced from RR'CHNO2 reduction, microsomal NADPH-dependent oxidation of the corresponding hydroxylamine RR'CHNHOH, or interaction of the nitrosodimer (RR'CHNO)2 with reduced cytochrome P-450. All the reported results are consistent with the involvement of a new class of ligands of cytochrome P-450-Fe(II), which are the unstable aliphatic nitrosomonomers RR'CHNO, whose nitroso group is isoelectronic with dioxygen and whose stabilisation results from their strong binding to heme-Fe(II), thus explaining the observed inhibition of the hydroxylating function of cytochrome P-450.
