[Effect of gender and obesity on postprandial lipemia in non-diabetic normolipidemic subjects and subjects with familial combined hyperlipidemia]. / Efecto del género y de la obesidad en la lipemia posprandial en sujetos sanos normolipidémicos no diabéticos y sujetos con hiperlipemia familiar combinada.

INTRODUCTION: A new method based on self-measurement of diurnal capillary triglycerides (TG) facilitates the study of postprandial lipemia (PL). The objectives of our study are: to evaluate the effect of gender and obesity on PL measured by self-determination of diurnal capillary TG with Accutrend GCT in normolipidemic non-diabetic subjects and subjects with familial combined hyperlipidemia (FCH). MATERIAL AND METHODS: We studied 23 FCH subjects (10 males) and 45 normolipidemic non-diabetic subjects (29 males). All subjects self-determine 3 diurnal capillary TG profiles during a week. RESULTS: In normolipidemic non diabetic subjects significantly higher diurnal TG profiles and area under the curve of TG (AUCTGc) (25.25 +/-9.09 vs 19.71 +/- 6.16 mmolh/l) were found in males compared to females. In FCH subjects these differences were not found and the AUCTGc correlated with BMI (r = 0.510, p < 0.05) and waist circumference (r = 0.453, p < 0.05). Obese subjects (BMI >or= 27 kg/m2) showed diurnal TG profiles and AUCTGc significantly higher than the non-obese. DISCUSSION: Normolipidemic non diabetic females showed a lower PL compared to males, probably due to the effect of estrogens in PL metabolism. Obesity negatively influences PL in normolipidemic non diabetic subjects and subjects with FCH.

Efecto del género y de la obesidad en la lipemia posprandial en sujetos sanos normolipidémicos no diabéticos y sujetos con hiperlipemia familiar combinada / Effect of gender and obesity on postprandial lipemia in non-diabetic normolipidemic subjects and subjects with familial combined hyperlipidemia

Introducción. Un nuevo método basado en la autodeterminación de triglicéridos (TG) capilares permite un mejor conocimiento de la lipemia posprandial (LP). Los objetivos de nuestro estudio son analizar el efecto del género y la obesidad sobre la LP valorada por medición capilar de TG diurnos mediante Accutrend GCT® en sujetos sanos y sujetos con hiperlipemia familiar combinada (HFC). Material y métodos. Hemos estudiado a 23 sujetos con HFC no relacionados entre sí (10 hombres) y a 45 sujetos (29 hombres) normolipidémicos no diabéticos. Todos ellos realizaron tres perfiles diarios de TG capilares durante una semana. Resultados. En los sujetos sanos normolipidémicos no diabéticos encontramos valores significativamente elevados en el perfil de TG capilares y área bajo la curva de TG capilares (ABCTGc) (25,25 ± 9,09 frente a 19,71 ± 6,16 mmolh/l) en el grupo de hombres frente al de las mujeres. En sujetos con HFC no se hallaron estas diferencias y el ABCTGc se correlacionó con el índice de masa corporal (IMC) (r = 0,510; p < 0,05) y el perímetro de la cintura (r = 0,453; p < 0,05). Al dividir los sujetos estudiados en dos grupos según el IMC, aquellos con IMC ≥ 27 kg/m2 presentaron valores de TG capilares diurnos y el ABCTGc significativamente superiores. Discusión. Las mujeres sanas normolipidémicas no diabéticas presentaron una menor lipemia posprandial que los hombres, probablemente por el efecto de los estrógenos sobre el metabolismo lipídico. La obesidad ejercía un efecto negativo sobre la lipemia posprandial, tanto en sujetos sanos como en sujetos con HFC (AU)

Introduction. A new method based on self-measurement of diurnal capillary triglycerides (TG) facilitates the study of postprandial lipemia (PL). The objectives of our study are: to evaluate the effect of gender and obesity on PL measured by self-determination of diurnal capillary TG with Accutrend GCT® in normolipidemic non-diabetic subjects and subjects with familial combined hyperlipidemia (FCH). Material y methods. We studied 23 FCH subjects (10 males) and 45 normolipidemic non-diabetic subjects (29 males). All subjects self-determine 3 diurnal capillary TG profiles during a week. Results. In normolipidemic non diabetic subjects significantly higher diurnal TG profiles and area under the curve of TG (AUCTGc) (25.25 ±9.09 vs 19.71 ± 6.16 mmolh/l) were found in males compared to females. In FCH subjects these differences were not found and the AUCTGc correlated with BMI (r = 0.510, p < 0.05) and waist circumference (r = 0.453, p < 0.05). Obese subjects (BMI ≥ 27 kg/m2) showed diurnal TG profiles and AUCTGc significantly higher than the non-obese. Discussion. Normolipidemic non diabetic females showed a lower PL compared to males, probably due to the effect of estrogens in PL metabolism. Obesity negatively influences PL in normolipidemic non diabetic subjects and subjects with FCH (AU)

Perfil diurno de triglicéridos en sujetos con hiperlipidemia familiar combinada de una población del sur de Europa / Diurnal triglyceride profile in subjects with familial combined hyperlipidemia in a southern european population

Objetivos. Comparar la lipidemia posprandial valorada por medición de los triglicéridos capilares (TGc) diurnos mediante Accutrend GCT® entre sujetos sanos y sujetos con hiperlipidemia familiar combinada (HFC), y relacionarla con parámetros antropométricos en una población del sur de Europa. Sujetos y método. Se ha analizado a 23 sujetos diagnosticados de HFC no relacionados entre sí (13 mujeres) y 45 sujetos sanos (26 mujeres) normolipémicos no diabéticos. En todos ellos se midieron de forma estandarizada parámetros antropométricos, perfil lipídico, insulinemia y HOMA (homeostasis model assessment) en ayunas. Además, se determinaron mediante Accutrend GCT® durante 3 días los TGc en 6 momentos: en ayunas, al acostarse y antes y 3 h después de la comida y cena. Resultados. Los sujetos con HFC presentaron significativamente mayores concentraciones de insulinemia, HOMA, TGc diurnos y área bajo la curva de TGc que los controles. Tanto en sujetos sanos como en sujetos con HFC el área bajo la curva de TGc, como expresión de la lipidemia posprandial, se correlacionó de forma positiva con el tipo y grado de obesidad. Conclusiones. La HFC es un modelo genético de hiperlipidemia posprandial. La obesidad y el depósito de grasa abdominal se relacionan con la lipidemia posprandial, probablemente por medio de la resistencia a la insulina (AU)

Objectives. To compare postprandial lipidemia, evaluated by diurnal capillary triglyceride (cTG) profile measured with Accutrend GCT®, between control and familial combined hyperlipidemic (FCH) subjects from a Southern European population. Subjects and method. 23 non related FCH subjects (13 women) and 45 non-diabetic normolipidemic controls (26 women) were studied. Anthropometric parameters, lipid profile, insulinemia and HOMA were measured in fasting state in all. In addition, TGc were determined by Accutrend GCT® for 3 days at 6 points: fasting, bedtime and before and 3 hours after dinner and lunch, respectively. Results. FCH subjects showed significantly higher fasting insulinemia, HOMA values, TGc and area under the curve of TGc (AUCTGc) compared with controls. AUCTGc, as expression of postprandial lipidemia, correlated positively with obesity in all subjects. Conclusions: FCH is a genetic model of postprandial hyperlipidemia. Obesity and abdominal fat deposits are positively related to postprandial lipidemia, probably due to insulin resistance (AU)

Adrenocortical scintigraphy with 131I-6-beta-iodomethyl-norcholesterol (NP 59) in bilateral adrenocortical carcinoma.

A case of a 49-year-old man suffering from bilateral adrenocortical carcinoma with local and secondary rapid progression is reported. The results of adrenocortical scintigraphy (NP 59) and histological findings allowed the diagnosis. This case report and a literature review showed the importance of using adrenocortical scintigraphy as a complementary imaging procedure of CT or MR images.