[Determinants of postprandial lipemia measured as diurnal triglyceride profile in non diabetic normolipidemic subjects]. / Determinantes de la lipemia posprandial medida como perfil diurno de triglicéridos en personas no diabéticas con normolipemia.

BACKGROUND AND OBJECTIVE: We decided to evaluate the clinical and biochemical predictors of postprandial lipemia, measured as daylong capillarly triglycerides (TGc) profiles, in normolipidemic non diabetic subjects. PATIENTS AND METHOD: We studied 76 normolipidemic non diabetic subjects (45 premenopausal females). Accutrend was used to measure daylong TGc profiles during 3 days in 6 previously standardized points: fasting, pre and 3 h after dinner and lunch and at bedtime. The area under the curve of TGc (AUC-TGc) was determined as expression of postprandial lipemia. RESULTS: Males showed significantly higher AUC-TGc (26.20 [11.00] vs 19.12 [6.57] in females; p < 0.001). Obese showed significantly higher values of AUC-TGc (27.87 [12.47] vs 20.05 [7.04]; p < 0.01). The AUC-TGc correlated with: age (r = 0.242; p < 0.05), body mass index (r = 0.312; p < 0.01), waist circumference (r = 0.394; p < 0.01), fasting plasma triglyceride (r = 0.634; p < 0.001), fasting insulinemia (r = 0.485; p < 0.001) and fasting HOMA (r = 0.484; p < 0.001). The multivariate analysis showed that HOMA (regression coefficient: 0.352; p = 0.02) and waist circumference (regression coefficient: 0.4; p = 0.05) were independent predictors of the AUC-TGc. CONCLUSIONS: Independent determinants of postprandial lipemia were waist circumference and HOMA.

Determinantes de la lipemia posprandial medida como perfil diurno de triglicéridos en personas no diabéticas con normolipemia / Determinants of postprandial lipemia measured as diurnal triglyceride profile in non diabetic normolipidemic subjects

Fundamento y objetivo: Conocer los determinantes clínicos y biológicos de la lipemia posprandial, medida con la autodeterminación diurna de triglicéridos en sangre capilar (TGc), en personas sin dislipemia ni diabetes. Pacientes y método: Hemos estudiado a 76 personas sanas (45 mujeres premenopáusicas) con normolipemia y sin diabetes. La determinación de los TGc se realizó mediante Accutrend® durante 3 días en 6 puntos establecidos: ayunas, inmediatamente antes y 3 h después de comer y de cenar, y antes de acostarse. Se midió el área bajo la curva de TGc (ABC-TGc) como expresión de la lipemia posprandial diurna. Resultados: El ABC-TGc fue significativamente mayor en los varones (26,20 [11,00]) que en las mujeres (19,12 [6,57]) (p < 0,001). Los obesos presentaron valores mayores de ABC-TGc (27,87 [12,47] frente a 20,05 [7,04]; p < 0,01). El ABC-TGc se correlacionó con la edad (r = 0,242; p < 0,05), el índice de masa corporal (r = 0,312; p < 0,01), el perímetro de la cintura (r = 0,394; p < 0,01), los triglicéridos plasmáticos en ayunas (r = 0,634; p < 0,001), la insulinemia en ayunas (r = 0,485; p < 0,001) y el índice HOMA en ayunas (r = 0,484; p < 0,001). El análisis del estudio multivariante mostró que el índice HOMA (coeficiente de regresión de 0,352; p = 0,02) y el perímetro de la cintura (coeficiente de regresión de 0,4; p = 0,05) predicen de forma independiente el ABC-TGc. Conclusiones: Los determinantes independientes de la lipemia posprandial en nuestra población son el perímetro de la cintura y el HOMA

Background and objective: We decided to evaluate the clinical and biochemical predictors of postprandial lipemia, measured as daylong capillarly triglycerides (TGc) profiles, in normolipidemic non diabetic subjects. Patients and method: We studied 76 normolipidemic non diabetic subjects (45 premenopausal females). Accutrend® was used to measure daylong TGc profiles during 3 days in 6 previously standarized points: fasting, pre and 3 h after dinner and lunch and at bedtime. The area unther the curve of TGc (AUC-TGc) was determined as expresion of postprandial lipemia. Results: Males showed significantly higher AUC-TGc (26.20 [11.00] vs 19.12 [6.57] in females; p < 0.001). Obese showed significantly higher values of AUC-TGc (27.87 [12.47] vs 20.05 [7.04]; p < 0.01). The AUC-TGc corelated with: age (r = 0.242; p < 0.05), body mass index (r = 0.312; p < 0.01), waist circumference (r = 0.394; p < 0.01), fasting plasma triglyceride (r = 0.634; p < 0.001), fasting insulinemia (r = 0.485; p < 0.001) and fasting HOMA (r = 0.484; p < 0.001). The multivariate analysis showed that HOMA (regression coeficent: 0.352; p = 0.02) and waist circumference (regression coeficent: 0.4; p = 0.05) were independent predictors of the AUC-TGc. Conclusions: Independent determinants of postprandial lipemia were waist circumference and HOMA