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Biochemistry ; 59(33): 3019-3025, 2020 08 25.
Article in English | MEDLINE | ID: mdl-32794692

ABSTRACT

Metal nanoparticles (AgNPs and ZnONPs) were synthesized using a green methodology with the green leaves extract of the Bedu (Ficus palmata) tree as a reducing agent and the support of natural fibers. The synthesized AgNPs and ZnONPs were characterized by several techniques, including ultraviolet-visible spectral analysis, powder X-ray diffraction crystal analysis, scanning electron microscopy, EDAX, transmission electron microscopy, and Fourier transform infrared spectroscopy, which confirmed that the synthesized particles are in the nano range (1-100 nm), i.e., 30 nm for AgNPs with polydispersity and a spherical shape, whereas the average size of synthesized ZnONPs is 34 nm and they seem to exhibit a distorted spherical shape. The results of thermogravimetric analysis confirmed a weight loss of 18.02% for AgNPs under exothermic conditions due to the desorption of water, and ZnONPs show weight loss between 265 and 500 °C. Both synthesized MNPs are highly thermally stable. Anti-inflammatory and anti-diabetic studies of metal NPs have been evaluated. The AgNPs and ZnONPs of F. palmata leaves showed remarkably highly potent activity for respective strains. In vitro anti-diabetic activity was found for inhibition of α-amylases and α-glucosidases by synthesized silver nanoparticles.


Subject(s)
Anti-Inflammatory Agents , Ficus/chemistry , Hypoglycemic Agents , Metal Nanoparticles/chemistry , Plant Extracts , Plant Leaves/chemistry , Anti-Inflammatory Agents/chemical synthesis , Anti-Inflammatory Agents/chemistry , Anti-Inflammatory Agents/isolation & purification , Anti-Inflammatory Agents/pharmacology , Cells, Cultured , Erythrocytes/cytology , Erythrocytes/drug effects , Glycoside Hydrolase Inhibitors/chemical synthesis , Glycoside Hydrolase Inhibitors/chemistry , Glycoside Hydrolase Inhibitors/pharmacology , Green Chemistry Technology/methods , Humans , Hypoglycemic Agents/chemical synthesis , Hypoglycemic Agents/chemistry , Hypoglycemic Agents/isolation & purification , Hypoglycemic Agents/pharmacology , Inhibitory Concentration 50 , Plant Extracts/chemistry , Plant Extracts/isolation & purification , Plant Extracts/pharmacology , Silver/chemistry , Spectroscopy, Fourier Transform Infrared , X-Ray Diffraction , Zinc/chemistry , alpha-Amylases/antagonists & inhibitors , alpha-Glucosidases/drug effects , alpha-Glucosidases/metabolism
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