1.
J Ocul Pharmacol
; 10(1): 289-93, 1994.
Article
in English
| MEDLINE
| ID: mdl-8207332
ABSTRACT
Loteprednol etabonate (LE) is a novel steroid with a low tendency to raise IOP. It is metabolized in the eye to an inactive metabolite. The current study was undertaken to assess the intra-ocular anti-inflammatory activity of LE in two models of experimental uveitis in rabbits. In the endotoxin induced rabbit model, LE was effective at reducing measures of inflammation, but less so that either fluorometholone (FML) or dexamethasone. In the Freunds adjuvant chronic uveitis model, FML was also very effective with LE and dexamethasone showing similar activity. The data demonstrate that LE is effective at reducing intra-ocular inflammation.
Subject(s)
Androstadienes/therapeutic use , Anti-Inflammatory Agents/therapeutic use , Uveitis, Anterior/drug therapy , Androstadienes/administration & dosage , Animals , Anti-Inflammatory Agents/administration & dosage , Chronic Disease , Dexamethasone/administration & dosage , Dexamethasone/therapeutic use , Disease Models, Animal , Fluorometholone/administration & dosage , Fluorometholone/therapeutic use , Intraocular Pressure , Loteprednol Etabonate , Ophthalmic Solutions , Rabbits , Uveitis, Anterior/chemically induced , Uveitis, Anterior/pathology
2.
J Charles H. Tweed Int Found
; 12: 100-11, 1984 Apr.
Article
in English
| MEDLINE
| ID: mdl-6401160