ABSTRACT
We report the clinical outcome and prognostic factors in 39 cases of childhood Japanese Encephalitis admitted to a tertiary hospital of Upper Assam and followed up for 421 days in the community. The mortality rate was 20.5% in our study. The mean GCS (9.97 +/- 0.91) was higher in surviving cases than the fatal cases (GCS 7.5 +/- 1.78) at admission. The fatal cases died within 4.75 +/- 3.19 days in the hospital. All the patients had low BMI (surviving cases 13.54 +/- 2.3; fatal cases 12.05 +/- 0.12) and were anemic. Cerebrospinal fluid (CSF) was clear in 91.4% cases but pressure and protein content were increased in all cases. About 10% cases had parkinsonian features at the time of discharge. Residual symptoms remained in about one third of cases even after 421 days.
Subject(s)
Encephalitis, Japanese , Child , Child, Preschool , Encephalitis, Japanese/diagnosis , Encephalitis, Japanese/mortality , Female , Glasgow Coma Scale , Humans , India/epidemiology , Male , PrognosisABSTRACT
Platinum-acridine conjugates were prepared from [PtCl2(ethane-1,2-diamine)] and the novel acridinylthioureas MeHNC(S)NMeAcr (6) and MeHNC(S)NMe(CH2CH2)NHAcr (15) by replacing one chloro leaving group in the cisplatin analogue with thiourea sulfur. In HL-60 leukemia cells, IC(50) values for 7 (Pt-tethered 6) and 16 (Pt-tethered 15) were 75 and 0.13 microM, respectively. In the ovarian cell lines 2008 and C13, 16 was active at micromolar concentrations and showed only partial cross-resistance with clinical cisplatin. Possible structure-activity relationships are discussed.
Subject(s)
Acridines/chemical synthesis , Antineoplastic Agents/chemical synthesis , Organoplatinum Compounds/chemical synthesis , Thiourea/analogs & derivatives , Thiourea/chemical synthesis , Acridines/chemistry , Acridines/pharmacology , Antineoplastic Agents/chemistry , Antineoplastic Agents/pharmacology , Cisplatin/pharmacology , Drug Design , Drug Resistance, Neoplasm , Drug Screening Assays, Antitumor , Humans , Magnetic Resonance Spectroscopy , Organoplatinum Compounds/chemistry , Organoplatinum Compounds/pharmacology , Structure-Activity Relationship , Thiourea/chemistry , Thiourea/pharmacology , Tumor Cells, CulturedSubject(s)
Dengue/complications , Hemorrhage/etiology , Dengue/mortality , Humans , India , Rural PopulationABSTRACT
In a hospital based study in Dibrugarh upper Assam carried out over a period of one year, 250 normal individuals, were screened for antibody to Japanese encephalitis Virus. 44 individuals (17.6%) showed antibody to JE virus. The highest numbers were found in July and August, each 40%, and lowest in January (4%). The ratio of apparent to inapparent infection in this study was found to be 9.1 : 100, which is lower than reported in Assam earlier, but slightly higher than predicted for India as a whole.
Subject(s)
Antibodies, Viral/blood , Encephalitis Viruses, Japanese/immunology , Encephalitis, Arbovirus/immunology , Adolescent , Adult , Age Distribution , Child , Child, Preschool , Encephalitis, Arbovirus/epidemiology , Humans , India/epidemiology , Infant , Mass Screening , Seasons , Seroepidemiologic StudiesABSTRACT
"In this paper a numerical method has been developed to project the total population of a geographical region. The method has been applied to the Indian situation. It is found that the total population of India was expected to lie between [836 million and 850 million in 1991 and between 986 million and 1,042 million] in 2001."
