Cortical signatures of auditory looming bias show cue-specific adaptation between newborns and young adults.

Adaptive biases in favor of approaching, or "looming", sounds have been found across ages and species, thereby implicating the potential of their evolutionary origin and universal basis. The human auditory system is well-developed at birth, yet spatial hearing abilities further develop with age. To disentangle the speculated inborn, evolutionary component of the auditory looming bias from its learned counterpart, we collected high-density electroencephalographic data across human adults and newborns. As distance-motion cues we manipulated either the sound's intensity or spectral shape, which is pinna-induced and thus prenatally inaccessible. Through cortical source localisation we demonstrated the emergence of the bias in both age groups at the level of Heschl's gyrus. Adults exhibited the bias in both attentive and inattentive states; yet differences in amplitude and latency appeared based on attention and cue type. Contrary to the adults, in newborns the bias was elicited only through manipulations of intensity and not spectral cues. We conclude that the looming bias comprises innate components while flexibly incorporating the spatial cues acquired through lifelong exposure.

Effects of individualized brain anatomies and EEG electrode positions on inferred activity of the primary auditory cortex.

Due to its high temporal resolution and non-invasive nature, electroencephalography (EEG) is considered a method of great value for the field of auditory cognitive neuroscience. In performing source space analyses, localization accuracy poses a bottleneck, which precise forward models based on individualized attributes such as subject anatomy or electrode locations aim to overcome. Yet acquiring anatomical images or localizing EEG electrodes requires significant additional funds and processing time, making it an oftentimes inaccessible asset. Neuroscientific software offers template solutions, on which analyses can be based. For localizing the source of auditory evoked responses, we here compared the results of employing such template anatomies and electrode positions versus the subject-specific ones, as well as combinations of the two. All considered cases represented approaches commonly used in electrophysiological studies. We considered differences between two commonly used inverse solutions (dSPM, sLORETA) and targeted the primary auditory cortex; a notoriously small cortical region that is located within the lateral sulcus, thus particularly prone to errors in localization. Through systematical comparison of early evoked component metrics and spatial leakage, we assessed how the individualization steps impacted the analyses outcomes. Both electrode locations as well as subject anatomies were found to have an effect, which though varied based on the configuration considered. When comparing the inverse solutions, we moreover found that dSPM more consistently benefited from individualization of subject morphologies compared to sLORETA, suggesting it to be the better choice for auditory cortex localization.

Action planning and affective states within the auditory peripersonal space in normal hearing and cochlear-implanted listeners.

Fast reaction to approaching stimuli is vital for survival. When sounds enter the auditory peripersonal space (PPS), sounds perceived as being nearer elicit higher motor cortex activation. There is a close relationship between motor preparation and the perceptual components of sounds, particularly of highly arousing sounds. Here we compared the ability to recognize, evaluate, and react to affective stimuli entering the PPS between 20 normal-hearing (NH, 7 women) and 10 cochlear-implanted (CI, 3 women) subjects. The subjects were asked to quickly flex their arm in reaction to positive (P), negative (N), and neutral (Nu) affective sounds ending virtually at five distances from their body. Pre-motor reaction time (pm-RT) was detected via electromyography from the postural muscles to measure action anticipation at the sound-stopping distance; the sounds were also evaluated for their perceived level of valence and arousal. While both groups were able to localize sound distance, only the NH group modulated their pm-RT based on the perceived sound distance. Furthermore, when the sound carried no affective components, the pm-RT to the Nu sounds was shorter compared to the P and the N sounds for both groups. Only the NH group perceived the closer sounds as more arousing than the distant sounds, whereas both groups perceived sound valence similarly. Our findings underline the role of emotional states in action preparation and describe the perceptual components essential for prompt reaction to sounds approaching the peripersonal space.