[Molecular genetic markers in evaluating risk of cardiovascular diseases in coal miners of Ukraine].

Left ventricle hypertrophy increases risk of cardiac failure and influences life expectancy. The authors demonstrated diagnostic reliability of genetic markers in evaluating left ventricle hypertrophy formation and their advantages over clinical signs, as outlines prognosis of diseases development on preclinical stage. Through genetic markers analysis with consideration of echo-cardiographic values of left ventricle myocardial weight, the authors determined genotypes associated with left ventricle hypertrophy development.

[High resolution CT to diagnose early stages of pneumoconiosis caused by coal dust].

The article deals with results obtained in analysis of high-resolution CT data for 177 coal miners with suspected pneumoconiosis.

[The early clinical signs of bronchopulmonary pathology in workers exposed to organic dust].

144 workers of two Ukrainian fodder production plants have been examined. Respiratory troubles such as chest tightness, cough with phlegm, wheezing were revealed not only in the group of workers exposed to high levels of endotoxins but also in the group exposed to low concentrations. The prevalence of ODTS (Organic Dust Toxic Syndrome), mucosal irritation syndrome, bronchial hyperresponsiveness and obstructive changes of lung function were related to levels of endotoxins in the air of work zone. Respiratory challenge test is the principal to reveal the early signs of obstructive changes of lung function. The protective measures for prophylaxy of the development of occupational diseases in workers exposed to organic dust were proposed.

[Substantiation of preclinical manifestations of bronchopulmonary diseases in workers exposed to organic dust]. / Obhruntuvannia doklinichnykh proiaviv urazhennia bronkholehenevoï systemy u robitnykiv, iaki zaznaiut' vplyvu orhanichnoho pylu.

144 workers of two Ukrainian fodder plants have been examined. Respiratory troubles presenting as cough, expectoration, shortness of breath have come to be the case from not only exposure to high concentrations of endotoxins but from low-level exposures as well. The prevalence of the toxic organic dust syndrome, musocal irritation syndrome, bronchial hyper-reactivity and obstructive changes in the ventilation function of the lungs have been found out to be associated with endotoxin levels in the air of the work environment of the production floor-area. Regarded as valid screenring procedures to early identify those persons predisposed to obstructive changes in the function of external respiration are pharmacological loading tests. Sanitary-and-hygienic and treatment-and-prophylactic measures are proposed to prevent development of occupational diseases in workers exposed to organic dust.

[Classification of pneumoconiosis]. / O klassifikatsii pnevmokonioza.

The article presents a modern classification of pneumoconiosis taking account of the international classification and experience gained by specialists in this country.

[Bronchial-pulmonary pathology and its early diagnosis in workers of combined fodder industry]. / Patologiia bronkholegochnoi sistemy u rabochikh proizvodstva kombikormov i ee ranniaia diagnostika.

The article is devoted to the question of peculiarity of bronchopulmonary system's pathology in the workers of the animal fodder production. The production dust contains high concentrations of endotoxins and leads to the development of allergic reactions and diseases of respiratory system. The ODTS (organic dust toxic syndrome) revealed as an acute reaction of organism in (39.7 +/- 4.4) % workers of the 1st plant and in (14.7 +/- 6.0) % of the 2nd one. Among chronic diseases predominates chronic bronchitis: (26.4 +/- 4.0) % at the I and (8.8 +/- 4.8) % at the II plants. We propose to use the obstruction of little bronchi and bronchial hyperresponsivennes as early diagnostical criterions of the influence of organic dust.