Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Database
Language
Publication year range
1.
Pure Appl Chem ; 70(2): 263-6, 1998 Feb.
Article in English | MEDLINE | ID: mdl-11542721

ABSTRACT

A research program has applied the tools of synthetic organic chemistry to systematically modify the structure of DNA and RNA oligonucleotides to learn more about the chemical principles underlying their ability to store and transmit genetic information. Oligonucleotides (as opposed to nucleosides) have long been overlooked by synthetic organic chemists as targets for structural modification. Synthetic chemistry has now yielded oligonucleotides with 12 replicatable letters, modified backbones, and new insight into why Nature chose the oligonucleotide structures that she did.


Subject(s)
DNA/chemistry , Molecular Biology/trends , Nucleic Acids/chemistry , Oligonucleotides/chemical synthesis , Catalysis , Codon , Molecular Structure , Nucleic Acids/chemical synthesis , Oligonucleotides/chemistry , Phosphates/chemistry , Sulfones/chemistry
SELECTION OF CITATIONS
SEARCH DETAIL
...