ABSTRACT
Anti-histidyl (Jo-1) antibodies have been implicated in the pathogenesis of anti-synthetase syndrome (ASS). A case is presented of a 55-year-old male patient presenting with pyrexia of unknown origin and inconclusive routine investigations. (18)F-FDG PET/CT was performed to locate any abnormal focus, which showed increased FDG uptake in the proximal shoulder muscles, as well as lung lesions. Subsequent investigation showed the presence of anti Jo-1 antibody, and diagnosed as an anti-synthetase syndrome. The patient was successfully treated with glucocorticoids and cyclophosphamide, and the response was assessed with symptomatic relief and disappearance of FDG uptake in lung and muscle lesions on post-treatment FDG PET/CT.
Subject(s)
Fever of Unknown Origin/etiology , Fluorodeoxyglucose F18 , Myositis/complications , Positron Emission Tomography Computed Tomography , Radiopharmaceuticals , Antibodies, Antinuclear/analysis , Humans , Male , Middle Aged , Myositis/immunologySubject(s)
Abscess/diagnostic imaging , Urinoma/diagnostic imaging , Adenocarcinoma/diagnostic imaging , Adenocarcinoma/secondary , Bone Neoplasms/diagnostic imaging , Bone Neoplasms/secondary , Cysteine/analogs & derivatives , Cysteine/pharmacokinetics , Diagnosis, Differential , Escherichia coli Infections/diagnostic imaging , Humans , Hyperemia/diagnostic imaging , Male , Middle Aged , Organotechnetium Compounds/pharmacokinetics , Prostatic Neoplasms/pathology , Radiopharmaceuticals/pharmacokinetics , Single Photon Emission Computed Tomography Computed Tomography , Technetium Tc 99m Medronate/pharmacokinetics , Urinary Tract Infections/diagnostic imaging , UrodynamicsABSTRACT
Hydronephrosis is a common finding in urinary tract outflow obstruction. Chronically obstructed hydronephrotic system may be associated with parenchymal changes. Ultrasound, intravenous urography, micturating cysto-urethrogram and scintigraphy are commonly performed to evaluate the cause of obstruction. In childhood, pelviureteric junction obstruction is a common cause of the hydronephrosis. Hydronephrosis can also be present in horseshoe kidneys due to poor drainage. However, a large sized hydronephrotic cavity may obscure the finding of horseshoe kidney. A case was reported, and it was diagnosed as horseshoe kidney on follow-up renal dynamic scan and confirmed with the help of dimercaptosuccinic acid SPECT/CT.
