Subject(s)
Oocyte Donation/psychology , Adult , Female , Follow-Up Studies , Humans , North Carolina , Retrospective Studies , Surveys and QuestionnairesABSTRACT
OBJECTIVE: To review published data pertaining to safety of psychoactive drugs used to treat psychiatric disorders during pregnancy and lactation. DATA SOURCES: A computerized search of articles published through July 1995 was performed on the MEDLINE data base. Additional sources were identified through cross-referencing. METHODS OF STUDY SELECTION: All identified references were reviewed with particular attention given to study design. DATA EXTRACTION AND SYNTHESIS: Each reference was reviewed to determine the safety of psychoactive agents to treat depression, bipolar disease, schizophrenia, and anxiety during pregnancy and lactation. Prospective or large retrospective studies were given more importance than case reports. CONCLUSION: Psychoactive medications may be used during pregnancy. Because data on safety are largely retrospective, treatment decisions must be weighed carefully.
Subject(s)
Abnormalities, Drug-Induced , Fetus/drug effects , Pregnancy Complications/drug therapy , Pregnancy Complications/psychology , Psychotic Disorders/drug therapy , Psychotropic Drugs/therapeutic use , Puerperal Disorders/drug therapy , Puerperal Disorders/psychology , Female , Humans , Infant, Newborn , Lactation , Milk, Human/chemistry , Pregnancy , Psychotropic Drugs/adverse effectsABSTRACT
A patient in whom the "insensitive ovary syndrome" was followed by a successful pregnancy is reported and discussed. Conception occurred while this patient was receiving estrogen therapy. The marked differences in her ovarian responsivity to endogenous and exogenous gonadotropin stimulation remain enigmatic.
