ABSTRACT
Papillary adenoma of the nipple is a benign condition of the nipple that can be confused clinically with adenocarcinoma metastatic to the skin or Paget's disease. Deep biopsy of the nipple is necessary to make a histologic diagnosis. Complete excision of the nipple and the subareolar tissue is sufficient to effect a cure.
Subject(s)
Breast Neoplasms/pathology , Cystadenoma/pathology , Nipples/pathology , Adult , Breast Diseases/pathology , Dermatitis/pathology , Diagnosis, Differential , Female , HumansABSTRACT
A prospective blind trial was undertaken to assess the usefulness of commonly used tests to diagnose osteomyelitis underlying pressure sores. Sixty-one pressure sores were studied, with a histopathologic diagnosis from the ostectomy specimen being available in 52. White cell count, erythrocyte sedimentation rate, plain pelvic x-ray, technetium-99m bone scan, computerized tomography, and Jamshidi needle bone biopsy were studied. The most useful individual test was a needle bone biopsy, with a sensitivity of 73 percent and a specificity of 96 percent. Technetium-99m bone scans and computerized tomography are not indicated in the diagnosis of osteomyelitis associated with pressure sores. Plain pelvic x-ray, white cell count, and erythrocyte sedimentation rate, with a diagnosis of osteomyelitis if any test is positive, is the most sensitive (89 percent), specific (88 percent), noninvasive workup. Jamshidi needle biopsy may be useful where these tests are negative and a clinical suspicion of osteomyelitis remains. Extent of surgical debridement and antibiotic therapy can then be rationally decided on the basis of this information.
Subject(s)
Osteomyelitis/diagnosis , Pressure Ulcer/etiology , Biopsy, Needle , Humans , Osteomyelitis/complications , Osteomyelitis/pathology , Probability , Prospective Studies , Spinal Cord Injuries/complicationsABSTRACT
Two cases of soft-tissue infection resulting from antibiotic therapy given AIDS patients are presented. Operative treatment resulted in a closed wound in one patient. In the other patient, who suffered from recurrent acute illnesses, nonoperative treatment resulted in slow wound contraction and epithelialization without secondary wound complications. Wound sepsis did not occur, despite the absence of normal immune function. Operation and additional hospitalization, with their attendant risks, were avoided.
