Proposing Development of Community-based Physical Activity Park for Elderly Population of Pakistan.

Physical inactivity is known to be as performing less than 150 minutes of moderate- to vigorous-intensity physical activity per week. It poses a substantial risk for not only non-communicable, chronic diseases such as stroke, diabetes etc. but also contributes to the global mortality. Evidence suggests that the usual urban green environment is sturdily related to several health paybacks to the elderly population, which includes not only decreased cardiovascular mortality, Type 2 Diabetes risk, but overall improved physical, emotional, and mental health. It also invokes physical activity for community involvement, natural green curative sensory effect, spiritual boost, and leisure recreation to the elderly. Additionally, parks serve to perform activities like exercise, gardening, brisk walk or simply meditation in the natural environment. Unfortunately, in Pakistan, the urban green spaces like parks are scarce. Most people do not have access to well-designed parks. People over the age of 50 and above seem to be most affected by this deficiency. There is a need for specially designed parks that can address the challenges faced by elderly people while exercising. This study summarises the available evidence for designing special open area space in parks for the elderly population across Pakistan and highlights the need for further work to alleviate the global sickness of physical sedentariness among the elderly. Key Words: Older adults, Parks, Physical activity, Physical inactivity.

Effects of Covid-19 on physical activity and eating behaviours and their mutual relationship.

The study aimed to determine the relationship between physical activity and eating behaviours among the physical therapy students of various physical therapy institutes of Rawalpindi/Islamabad during the Covid-19 pandemic. The study was conducted from September 2020 to February 2021. It was a cross sectional co-relational survey of a total of 209 physical therapy students, and the sampling technique was purposive sampling. Eating Attitude Test (EAT-26) Questionnaire and International Physical Activity Questionnaire (IPAQ) were used as the data collection tools. Healthy young students of 18-26 years of age, of both genders, were included and students with major functional limitations were excluded from the study. The results showed that 87 (41.6%) participants had normal EAT-26 scores whereas 122 (58.4%) had abnormal EAT-26 scores. IPAQ scores were categorically distributed into low, moderate, and high levels of physical activity. Eighty-seven (41.6%) had low levels of physical activity, 106 (50.7%) had moderate levels of physical activity, and 16 (7.7%) had high levels of physical activity. Spearman Rho test of correlation was applied with the p-value 0.219, and R-value of correlation was 0.08, which showed weak positive correlation between physical activity and eating behaviours. The study concluded that restricted physical activity and home confinement due to Covid-19 pandemic, did not potentially affect the physical therapy students' eating behaviours.

Banana bunchy top virus genetic diversity in Pakistan and association of diversity with recombination in its genomes.

Banana Bunchy top virus (BBTV) is a multipartite circular single strand DNA virus that belongs to genus Babuvirus and family Nanoviridae. It causes significant crop losses worldwide and also in Pakistan. BBTV is present in Pakistan since 1988 however, till now only few (about twenty only) sequence of genomic components have been reported from the country. To have insights into current genetic diversity in Pakistan fifty-seven genomic components including five complete genomes (comprises of DNA-R, -U3, -S, -M, -C and -N components) were sequenced in this study. The genetic diversity analysis of populations from Pakistan showed that DNA-R is highly conserved followed by DNA-N, whereas DNA-U3 is highly diverse with the most diverse Common Region Stem-loop (CR-SL) in BBTV genome, a functional region, which previously been reported to have undergone recombination in Pakistani population. A Maximum Likelihood (ML) phylogenetic analysis of entire genomes of isolates by using sequence of all the components concatenated together with the reported genomes around the world revealed deeper insights about the origin of the disease in Pakistan. A comparison of the genetic diversity of Pakistani and entire BBTV populations around the world indicates that there exists a correlation between genetic diversity and recombination. Population genetics analysis indicated that the degree of selection pressure differs depending on the area and genomic component. A detailed analysis of recombination across various components and functional regions suggested that recombination is closely associated with the functional parts of BBTV genome showing high genetic diversity. Both genetic diversity and recombination analyses suggest that the CR-SL is a recombination hotspot in all BBTV genomes and among the six components DNA-U3 is the only recombined component that has extensively undergone inter and intragenomic recombination. Diversity analysis of recombinant regions results on average one and half fold increase and, in some cases up to four-fold increase due to recombination. These results suggest that recombination is significantly contributing to the genetic diversity of BBTV populations around the world.

The effects of Environmental Kuznets Curve toward environmental pollution, energy consumption on sustainable economic growth through moderate role of technological innovation.

South Asia is a hub for encompassing air contamination, with 37 of the top tiers of the 40 most contaminated urban communities around the globe (IQAIR, 2020). From this perspective, this research aims to explore the validity of the Environmental Kuznets Curve while controlling for the impacts of technological innovation and energy consumption on the sustainable economic growth-environmental pollution nexus in the backdrop of South Asian economies by using panel dataset from 1998 to 2018. Therefore, this analysis adopts a fully modified ordinary least square (FMOLS) approach for examination, which affirms the EKC hypothesis existence, suggesting that the environment in South Asia is deteriorating while technological innovations have moderated the impact. Moreover, the empirical findings indicate that energy consumption as well as technological innovations both have a significant positive impact on the CO2 emanations, which harms biodiversity.

The dynamic impact of renewable energy sources on environmental economic growth: evidence from selected Asian economies.

The linkage between renewable energy resources and environmental influences on economic growth among selected Asian economies play a vital role in sustainable economic development. This study encompasses the panel data sets for eight selected Asian countries, and the period starts from 1990 to 2018. This research relies on the panel vector error correction model (PVECM) for data estimation. The overall findings indicate that biomass, geothermal, and wind power sources of energy have a positive and significant impact on the economic advancement of Asian economies. Besides that, as opposed to the other two renewable energy sources, windpower has a greater impact on economic development. Furthermore, the empirical findings of current research have significant implications towards selected Asian countries' energy policy related to both private and public sector enterprises as it helps in identifying the industrial sectors which have greater contribution towards the economy and their energy requirements in long term.

Preclinical Evidence for the Pharmacological Actions of Glycyrrhizic Acid: A Comprehensive Review.

Glycyrrhiza glabra L. (Family: Fabaceae) is one of the important traditional medicinal plant used extensively in folk medicine. It is known for its ethnopharmacological value in curing a wide variety of ailments. Glycyrrhizin, an active compound of G. glabra, possesses anti-inflammatory activity due to which it is mostly used in traditional herbal medicine for the treatment and management of chronic diseases. The present review is focused extensively on the pharmacology, pharmacokinetics, toxicology, and potential effects of Glycyrrhizic Acid (GA). A thorough literature survey was conducted to identify various studies that reported on the GA on PubMed, Science Direct and Google Scholar.