ABSTRACT
The Authors describe their experience with a combination therapy with carmustine (BCNU), cyclophosphamide (CTX) plus adriamycin (ADM) in the treatment of advanced ovarian cancer. The complete remission was obtained in 33.3% of subjects, the partial remission in 37.5%. Almost all patients suffered nausea, vomiting and alopecia. Myelosuppression was acceptable. No heart damage was observed. This pharmacological association can be considered an effective medical treatment in the management of ovarian carcinomas in advanced stages.
Subject(s)
Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Ovarian Neoplasms/drug therapy , Adenocarcinoma/drug therapy , Adult , Aged , Antineoplastic Combined Chemotherapy Protocols/adverse effects , Carcinoma/drug therapy , Carmustine/administration & dosage , Cisplatin/therapeutic use , Cyclophosphamide/administration & dosage , Cystadenocarcinoma/drug therapy , Doxorubicin/administration & dosage , Female , Humans , Middle AgedABSTRACT
Brenner's tumor is a rare fibroepithelial ovarian neoplasia, histologically characterized by an epithelial component similar to the transitional epithelium of the urinary tract. The histogenesis of neoplasm, which only rarely secretes estrogens, is still controversial. The Authors describe the clinical and anatomopathological features of six cases come to their observation. Only one of these was malignant; the woman died 18 months after diagnosis. There is no strict correlation between histological picture and biological behaviour. Only this one can give assurance on the benign or malignant nature of Brenner's tumor.
Subject(s)
Brenner Tumor/pathology , Ovarian Neoplasms/pathology , Adult , Aged , Diagnosis, Differential , Female , Humans , Middle Aged , Ovarian Cysts/pathologyABSTRACT
The Authors report a critical review of all the cases of ovarian neoplasia observed in the provinces of Pisa, Livorno, Lucca and La Spezia between 1976 and 1981. This study does not take into account all the cases in which incomplete clinical and histologic data were available or the first histologic diagnosis was not confirmed by a second examination. The incidence rate and distribution characteristics of all the histologic types of ovarian neoplasia are described.
