ABSTRACT
A new reticulate hernioprosthesis has been developed and proposed for clinical use. The adhesive high molecular polymer coating containing silver nanoclusters was applied on the lavsan network. After implantation the polymer was dissolved in the tissue fluid and formed the hollows between the threads facilitating invasion of the connective tissue into the network. The prolonged antimicrobial effect was proved to stay in the wound tissue as long as 5 days. Silver nanoclusters prevent the formation of microbial biofilms and development of suppuration around the prosthesis. Its unique properties are confirmed by positive results of its clinical use.
Subject(s)
Coated Materials, Biocompatible , Herniorrhaphy , Metal Nanoparticles , Silver/therapeutic use , Surgical Mesh , Surgical Wound Infection/prevention & control , Adult , Aged , Aged, 80 and over , Animals , Biofilms/drug effects , Disease Models, Animal , Female , Follow-Up Studies , Guinea Pigs , Humans , Male , Middle Aged , Surgical Wound Infection/microbiology , Treatment Outcome , Young AdultABSTRACT
35 procedures of plasmofiltration were conducted on the test series of domestic membrane plasmofilter in 25 patients suffering from atopic diseases, systemic affections of connective tissue, advanced atherosclerosis, etc. The filter proved promising in therapeutic patients. The procedure is easier to perform compared to centrifuge plasmapheresis, it can work under thin blood flow. However, centrifuge plasmapheresis has advantages over the above filtration in patients with hyperhydration, hemorrhagic syndrome, contraindications to large-dose anticoagulants.
Subject(s)
Hemofiltration/instrumentation , Membranes, Artificial , Combined Modality Therapy , Hemofiltration/adverse effects , Humans , PlasmapheresisABSTRACT
We report 4 cases of neuromyelitis optic (Devic's disease), with 3 to 7 year-follow-up for 3 of them. Most of the data agreed with the previously reported cases: subacute onset, association of optic neuritis and myelitis within several weeks or months, absence of relapse, good prognosis for paraplegia but poor prognosis for visual loss, and effectiveness of corticosteroids on spinal cord involvement in 4 cases. Moreover these 4 cases have revealed the following rare features: unilateral visual disturbance (1 case), total recovery of visual signs (1 case) with only a short period of follow-up, onset during childhood (1 case), onset following an acute lymphocytic meningitis (1 case), and dependency from corticosteroid therapy (2 cases). None of the patients had obvious immunological disturbance. N.M.R. imaging revealed in 2 cases, disseminated demyelinated areas which confirmed neuropathological data from the literature, showing that anatomical lesions could be wider than expected on clinical signs. The poor visual prognosis, the serum inflammatory signs, the epidemiologic data, the high cell and protein levels in C.S.F., and the absence of relapse suggested, in our cases and in most of the previously reported ones, that neuromyelitis optic must be differentiated from multiple sclerosis.
Subject(s)
Demyelinating Diseases/diagnosis , Neuromyelitis Optica/diagnosis , Adrenal Cortex Hormones/therapeutic use , Adult , Child , Diagnosis, Differential , Female , Humans , Magnetic Resonance Imaging , Male , Middle Aged , Multiple Sclerosis/diagnosis , Neuromyelitis Optica/drug therapy , Neuromyelitis Optica/etiologyABSTRACT
Serum myoglobin radio-immuno-assay was performed in 137 patients with myocardial infarction. Two groups, of 102 and 35 patients respectively, were seen in two different hospitals. Serum myoglobin was increased in 72 patients from the first group, and in 30 patients from the second group. In 10 patients from the first group, during the first 24 hours, the increase in serum myoglobin was isolated, without increase in CPK, LDH or SGOT. In the second group, a high serum myoglobin level with normal CPK was found in five patients. Increased serum myoglobin is not a specific indicator of myocardial infarction.
