ABSTRACT
The paper describes an atypical case of simultaneous airborne and direct contact dermatitis in a beekeeper from the Malopolska region. This is the third such case described in a beekeeper in the world and the first in Poland. I suggest that propolis should be regarded as both a direct and airborne contact allergen in beekeepers.
Subject(s)
Beekeeping , Dermatitis, Allergic Contact/etiology , Facial Dermatoses/etiology , Hand Dermatoses/etiology , Propolis/adverse effects , Air Pollutants, Occupational/adverse effects , Humans , Male , Middle Aged , PolandABSTRACT
A library of ethylene analogs of the previously described arylpiperazines with N-acylated amino acids was synthesized on SynPhase Lanterns and the library representatives were evaluated for their 5-HT(1A) and 5-HT(2A) receptor affinities. The obtained results were compared with those reported for compounds containing propylene and a butylene spacer and they revealed that 5-HT(1A) receptor affinity decreased proportionally with the length of the alkyl chain. Furthermore, the synthesized 3-cycloalkyl derivatives containing two methylene group spacers showed that the 3-position of pyrrolidine-2,5-dione preferred substituents of hydrophobic character.
